LIG1 binds APEX1 and PCNA at SSB

Stable Identifier
R-HSA-110371
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interaction of APE1 with DNA ligase I
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LIG1 (DNA ligase I) is recruited to the long-patch base excision repair site through direct interaction with APEX1 (Ranalli et al. 2002), PCNA (Montecucco et al. 1998, Levin et al. 2000) and RFC (Vijayakumar et al. 2009). The binding of LIG1 to RFC is negatively regulated by LIG1 phosphorylation (Vijaykumar et al. 2009, Peng et al. 2012).

Literature References
PubMed ID Title Journal Year
10959839 Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.

Levin, DS, McKenna, AE, Motycka, TA, Matsumoto, Y, Tomkinson, AE

Curr Biol 2000
9649448 DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories

Montecucco, A, Rossi, R, Levin, DS, Gary, R, Park, MS, Motycka, TA, Ciarrocchi, G, Villa, A, Biamonti, G, Tomkinson, AE

EMBO J. 1998
19223468 Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair

Vijayakumar, S, Dziegielewska, B, Levin, DS, Song, W, Yin, J, Yang, A, Matsumoto, Y, Bermudez, VP, Hurwitz, J, Tomkinson, AE

Mol. Cell. Biol. 2009
22952233 Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Peng, Z, Liao, Z, Dziegielewska, B, Matsumoto, Y, Thomas, S, Wan, Y, Yang, A, Tomkinson, AE

J. Biol. Chem. 2012
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