Reactome | LIG1 binds APEX1 and PCNA at SSB

LIG1 binds APEX1 and PCNA at SSB

Stable Identifier

R-HSA-110371

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Interaction of APE1 with DNA ligase I

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LIG1 (DNA ligase I) is recruited to the long-patch base excision repair site through direct interaction with APEX1 (Ranalli et al. 2002), PCNA (Montecucco et al. 1998, Levin et al. 2000) and RFC (Vijayakumar et al. 2009). The binding of LIG1 to RFC is negatively regulated by LIG1 phosphorylation (Vijaykumar et al. 2009, Peng et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
10959839	Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair. Levin, DS, McKenna, AE, Motycka, TA, Matsumoto, Y, Tomkinson, AE	Curr Biol	2000
9649448	DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories Montecucco, A, Rossi, R, Levin, DS, Gary, R, Park, MS, Motycka, TA, Ciarrocchi, G, Villa, A, Biamonti, G, Tomkinson, AE	EMBO J.	1998
19223468	Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair Vijayakumar, S, Dziegielewska, B, Levin, DS, Song, W, Yin, J, Yang, A, Matsumoto, Y, Bermudez, VP, Hurwitz, J, Tomkinson, AE	Mol. Cell. Biol.	2009
22952233	Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair Peng, Z, Liao, Z, Dziegielewska, B, Matsumoto, Y, Thomas, S, Wan, Y, Yang, A, Tomkinson, AE	J. Biol. Chem.	2012