Cleavage of ethenocytosine by TDG glycosylase

Stable Identifier
R-HSA-110234
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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TDG, a G/T mismatch-specific DNA glycosylase, cleaves ethenocytosine mispaired with guanine, leaving an apurinic/apyrimidinic (AP) site in the DNA (Hang et al. 1998).

Literature References
PubMed ID Title Journal Year
9811839 A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Hang, B, Medina, M, Fraenkel-Conrat, H, Singer, B

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of TDG:EtCYT-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created