Cleavage of ethenocytosine by TDG glycosylase

Stable Identifier
R-HSA-110234
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of ethenocytosine by TDG glycosylase
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TDG, a G/T mismatch-specific DNA glycosylase, cleaves ethenocytosine mispaired with guanine, leaving an apurinic/apyrimidinic (AP) site in the DNA (Hang et al. 1998).
Literature References
PubMed ID Title Journal Year
9811839 A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Hang, B, Medina, M, Fraenkel-Conrat, H, Singer, B

Proc. Natl. Acad. Sci. U.S.A. 1998
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Catalyst Activity

DNA N-glycosylase activity of TDG:EtCYT-dsDNA [nucleoplasm]

Physical Entity
TDG:EtCYT-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
Cleavage of ethenocytosine by TDG glycosylase (Bos taurus)
Cleavage of ethenocytosine by TDG glycosylase (Canis familiaris)
Cleavage of ethenocytosine by TDG glycosylase (Danio rerio)
Cleavage of ethenocytosine by TDG glycosylase (Drosophila melanogaster)
Cleavage of ethenocytosine by TDG glycosylase (Gallus gallus)
Cleavage of ethenocytosine by TDG glycosylase (Mus musculus)
Cleavage of ethenocytosine by TDG glycosylase (Rattus norvegicus)
Cleavage of ethenocytosine by TDG glycosylase (Schizosaccharomyces pombe)
Cleavage of ethenocytosine by TDG glycosylase (Sus scrofa)
Cleavage of ethenocytosine by TDG glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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