Cleavage of uracil by MBD4 glycosylase

Stable Identifier
R-HSA-110231
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves uracil mispaired with guanine at non-methylated CpG islands, leaving an apurinic/apyrimidinic (AP) DNA site (Petronzelli et al. 2000).

Literature References
PubMed ID Title Journal Year
11056019 Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

Petronzelli, F, Riccio, A, Markham, GD, Seeholzer, SH, Genuardi, M, Karbowski, M, Yeung, AT, Matsumoto, Y, Bellacosa, A

J. Cell. Physiol. 2000
Participants
Participates
Catalyst Activity

DNA N-glycosylase activity of MBD4:CpG(U:G)-dsDNA [nucleoplasm]

Orthologous Events
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