Cleavage of uracil by MBD4 glycosylase

Stable Identifier
R-HSA-110231
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of uracil by MBD4 glycosylase
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MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves uracil mispaired with guanine at non-methylated CpG islands, leaving an apurinic/apyrimidinic (AP) DNA site (Petronzelli et al. 2000).
Literature References
PubMed ID Title Journal Year
11056019 Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

Petronzelli, F, Riccio, A, Markham, GD, Seeholzer, SH, Genuardi, M, Karbowski, M, Yeung, AT, Matsumoto, Y, Bellacosa, A

J. Cell. Physiol. 2000
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Catalyst Activity

DNA N-glycosylase activity of MBD4:CpG(U:G)-dsDNA [nucleoplasm]

Physical Entity
MBD4:CpG(U:G)-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
Cleavage of uracil by MBD4 glycosylase (Bos taurus)
Cleavage of uracil by MBD4 glycosylase (Canis familiaris)
Cleavage of uracil by MBD4 glycosylase (Gallus gallus)
Cleavage of uracil by MBD4 glycosylase (Mus musculus)
Cleavage of uracil by MBD4 glycosylase (Rattus norvegicus)
Cleavage of uracil by MBD4 glycosylase (Sus scrofa)
Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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