Cleavage of 5-hydroxyluracil by UNG glycosylase

Stable Identifier
R-HSA-110217
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Cleavage of 5-hydroxyluracil by UNG glycosylase
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UNG, a DNA uracil glycosylase, cleaves 5-hydroxyuracil, generated by cytosine oxidation, from the DNA phosphate backbone, creating an apurinic/apyrimidinic (AP) site in the DNA (Dizdaroglu et al. 1996).

Literature References
PubMed ID Title Journal Year
8602352 Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

Dizdaroglu, M, Karakaya, A, Jaruga, P, Slupphaug, G, Krokan, HE

Nucleic Acids Res. 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
uracil DNA N-glycosylase activity of UNG-1:5-OHU-dsDNA [nucleoplasm]
Physical Entity
UNG-1:5-OHU-dsDNA [nucleoplasm]
Activity
uracil DNA N-glycosylase activity (0004844)
Orthologous Events
Cleavage of 5-hydroxyluracil by UNG glycosylase (Bos taurus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)