Cleavage of 5-hydroxyluracil by UNG glycosylase

Stable Identifier
R-HSA-110217
Type
Reaction
Species
Homo sapiens
Compartment
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General
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UNG, a DNA uracil glycosylase, cleaves 5-hydroxyuracil, generated by cytosine oxidation, from the DNA phosphate backbone, creating an apurinic/apyrimidinic (AP) site in the DNA (Dizdaroglu et al. 1996).

Literature References
PubMed ID Title Journal Year
8602352 Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

Krokan, HE, Karakaya, A, Slupphaug, G, Jaruga, P, Dizdaroglu, M

Nucleic Acids Res. 1996
Participants
Participates
Catalyst Activity

uracil DNA N-glycosylase activity of UNG-1:5-OHU-dsDNA [nucleoplasm]

Orthologous Events
Authored
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