UNG, a DNA uracil glycosylase, cleaves 5-hydroxyuracil, generated by cytosine oxidation, from the DNA phosphate backbone, creating an apurinic/apyrimidinic (AP) site in the DNA (Dizdaroglu et al. 1996).
Krokan, HE, Karakaya, A, Slupphaug, G, Jaruga, P, Dizdaroglu, M
uracil DNA N-glycosylase activity of UNG-1:5-OHU-dsDNA [nucleoplasm]
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