Cleavage of 5-hydroxyluracil by UNG glycosylase

Stable Identifier
R-HSA-110217
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of 5-hydroxyluracil by UNG glycosylase
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
UNG, a DNA uracil glycosylase, cleaves 5-hydroxyuracil, generated by cytosine oxidation, from the DNA phosphate backbone, creating an apurinic/apyrimidinic (AP) site in the DNA (Dizdaroglu et al. 1996).
Literature References
PubMed ID Title Journal Year
8602352 Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

Krokan, HE, Karakaya, A, Slupphaug, G, Jaruga, P, Dizdaroglu, M

Nucleic Acids Res. 1996
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Catalyst Activity

uracil DNA N-glycosylase activity of UNG-1:5-OHU-dsDNA [nucleoplasm]

Physical Entity
UNG-1:5-OHU-dsDNA [nucleoplasm] (Homo sapiens)
Activity
uracil DNA N-glycosylase activity (GO:0004844)
Orthologous Events
Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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