AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier
Reaction [transition]
Homo sapiens
(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]
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Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. Cytosolic adenylate kinases 5, 7, 8 and 9 (AK5, 7, 8 and 9) catalyze the reversible phosphorylation of (d)AMP and (d)CMP with ATP to form (d)ADP and (d)CDP, respectively, and ADP. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated (Panayiotou et al. 2011, Amiri et al. 2013). In the body AK5 expression was observed only in brain of nine tissues tested by Northern blotting (Van Rompay et al. 1999). AK5 is inferred to occur as a dimer from unpublished crystallographic data obtained for the catalytically active carboxyterminal third of the protein (PDB 2BWJ).

Literature References
PubMed ID Title Journal Year
23416111 The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase

Solaroli, N, Conserva, F, Karlsson, A, Panayiotou, C, Amiri, M

Int. J. Biochem. Cell Biol. 2013
10215863 Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein

Van Rompay, AR, Karlsson, A, Johansson, M

Eur J Biochem 1999
21080915 The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes

Solaroli, N, Xu, Y, Karlsson, A, Johansson, M, Panayiotou, C

Biochem. J. 2011
Event Information
Catalyst Activity

nucleoside kinase activity of AK5,7,8,9 [cytosol]

Orthologous Events
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