Reactome | AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier

R-HSA-110138

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]

ReviewStatus

5/5

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AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

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Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. Cytosolic adenylate kinases 5, 7, 8 and 9 (AK5, 7, 8 and 9) catalyze the reversible phosphorylation of (d)AMP and (d)CMP with ATP to form (d)ADP and (d)CDP, respectively, and ADP. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated (Panayiotou et al. 2011, Amiri et al. 2013). In the body AK5 expression was observed only in brain of nine tissues tested by Northern blotting (Van Rompay et al. 1999). AK5 is inferred to occur as a dimer from unpublished crystallographic data obtained for the catalytically active carboxyterminal third of the protein (PDB 2BWJ).

Literature References

PubMed ID	Title	Journal	Year
23416111	The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase Solaroli, N, Conserva, F, Karlsson, A, Panayiotou, C, Amiri, M	Int. J. Biochem. Cell Biol.	2013
10215863	Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein Van Rompay, AR, Karlsson, A, Johansson, M	Eur J Biochem	1999
21080915	The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes Solaroli, N, Xu, Y, Karlsson, A, Johansson, M, Panayiotou, C	Biochem. J.	2011