(d)GDP + ADP <=> (d)GMP + ATP (GUK1)

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GDP and dGDP with ADP to form GMP and dGMP respectively and ATP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).
Literature References
PubMed ID Title Journal Year
6248551 Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase

Miller, WH, Miller, RL

J Biol Chem 1980
177353 Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man

Harris, H, Jamil, T, Fisher, RA

Human Hered 1975
211390 Guanylate kinases from human erythrocytes, hog brain, and rat liver

Parks, Jr, RE, Agarwal, KC, Miech, RP

Methods Enzymol 1978
8663313 Cloning, characterization, and modeling of mouse and human guanylate kinases

Brady, WA, Black, ME, Kokoris, MS, Fitzgibbon, M

J Biol Chem 1996
Catalyst Activity

guanylate kinase activity of GUK1 [cytosol]

Orthologous Events
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