Formation of ERCC1:XPF heterodimeric complex

Stable Identifier
R-HSA-109955
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ERCC1 binds ERCC4 (XPF)
ReviewStatus
5/5
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Formation of ERCC1:XPF heterodimeric complex
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ERCC1 binds ERCC4 (XPF) to form a heterodimeric ERCC1:ERCC4 (ERCC1:XPF) complex with a DNA endonuclease activity, where ERCC4 is the catalytic subunit. Suitable substrates for the ERCC1:ERCC4 endonuclease are single strand DNA (ssDNA) and ssDNA region of a duplex DNA with an open bubble structure (Park et al. 1995).

Literature References
PubMed ID Title Journal Year
7559382 Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

Park, CH, Bessho, T, Sancar, A, Matsunaga, T

J. Biol. Chem. 1995
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Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)
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Authored
Gopinathrao, G  (2004-01-23)
Reviewed
Fousteri, M  (2015-08-03)
Created
Gopinathrao, G  (2004-01-23)
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