Formation of ERCC1:XPF heterodimeric complex

Stable Identifier
R-HSA-109955
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ERCC1 binds ERCC4 (XPF)
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of ERCC1:XPF heterodimeric complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ERCC1 binds ERCC4 (XPF) to form a heterodimeric ERCC1:ERCC4 (ERCC1:XPF) complex with a DNA endonuclease activity, where ERCC4 is the catalytic subunit. Suitable substrates for the ERCC1:ERCC4 endonuclease are single strand DNA (ssDNA) and ssDNA region of a duplex DNA with an open bubble structure (Park et al. 1995).
Literature References
PubMed ID Title Journal Year
7559382 Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

Park, CH, Bessho, T, Sancar, A, Matsunaga, T

J. Biol. Chem. 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
Formation of ERCC1:XPF heterodimeric complex (Bos taurus)
Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)
Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)
Formation of ERCC1:XPF heterodimeric complex (Danio rerio)
Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)
Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)
Formation of ERCC1:XPF heterodimeric complex (Mus musculus)
Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)
Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)
Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)
Formation of ERCC1:XPF heterodimeric complex (Sus scrofa)
Authored
Gopinathrao, G  (2004-01-23)
Reviewed
Fousteri, M  (2015-08-03)
Created
Gopinathrao, G  (2004-01-23)
Cite Us!