GRB2-1 binds SOS1

Stable Identifier
R-HSA-109813
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GRB2-1 binds SOS1
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In the cytoplasm of unstimulated cells, SOS1 is found in a complex with GRB2. The interaction occurs between the carboxy terminal domain of SOS1 and the Src homology 3 (SH3) domains of GRB2.
Literature References
PubMed ID Title Journal Year
8479541 Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

Yajnik, V, Skolnik, E, Batzer, A, Daly, R, Li, N, Schlessinger, J, Margolis, B

Nature 1993
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Orthologous Events
GRB2-1 binds SOS1 (Bos taurus)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Canis familiaris)
GRB2-1 binds SOS1 (Danio rerio)
GRB2-1 binds SOS1 (Drosophila melanogaster)
GRB2-1 binds SOS1 (Gallus gallus)
GRB2-1 binds SOS1 (Mus musculus)
GRB2-1 binds SOS1 (Rattus norvegicus)
GRB2-1 binds SOS1 (Sus scrofa)
GRB2-1 binds SOS1 (Xenopus tropicalis)
Authored
Charalambous, M  (2005-01-07)
Reviewed
Heldin, CH  (2008-02-12)
Created
Charalambous, M  (2004-04-29)
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