In the cytoplasm of unstimulated cells, SOS1 is found in a complex with GRB2. The interaction occurs between the carboxy terminal domain of SOS1 and the Src homology 3 (SH3) domains of GRB2.
Li, N, Batzer, A, Daly, R, Yajnik, V, Skolnik, E, Margolis, B, Schlessinger, J
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