Reactome | GRB2-1 binds SOS1

GRB2-1 binds SOS1

Stable Identifier

R-HSA-109813

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - GRB2 events in EGFR signaling (Homo sapiens)
      - GRB2-1 binds SOS1 (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - GRB2-1 binds SOS1 (Homo sapiens)

General

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In the cytoplasm of unstimulated cells, SOS1 is found in a complex with GRB2. The interaction occurs between the carboxy terminal domain of SOS1 and the Src homology 3 (SH3) domains of GRB2.

Literature References

PubMed ID	Title	Journal	Year
8479541	Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Yajnik, V, Skolnik, E, Batzer, A, Daly, R, Li, N, Schlessinger, J, Margolis, B	Nature	1993