Reactome | deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

Stable Identifier

R-HSA-109671

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

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Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions of deoxyadenosine and deoxyguanosine with ATP to form the corresponding nucleotide monophosphates and AMP, The enzyme is a dimer (Bohman and Eriksson 1988; Datta et al. 1989). While the enzyme can be found in nuclei of cultured cells expressing high levels of a tagged recombinant protein, its normal location appears to be cytosolic (Hatzis et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
2844225	Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme Bohman, C, Eriksson, S	Biochemistry	1988
9804782	The intracellular localization of deoxycytidine kinase Hatzis, P, Al-Madhoon, AS, Jullig, M, Petrakis, TG, Eriksson, S, Talianidis, I	J Biol Chem	1998
2539852	Human T-lymphoblast deoxycytidine kinase: purification and properties Datta, NS, Shewach, DS, Hurley, MC, Mitchell, BS, Fox, IH	Biochemistry	1989