deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

Stable Identifier
Homo sapiens
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Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions of deoxyadenosine and deoxyguanosine with ATP to form the corresponding nucleotide monophosphates and AMP, The enzyme is a dimer (Bohman and Eriksson 1988; Datta et al. 1989). While the enzyme can be found in nuclei of cultured cells expressing high levels of a tagged recombinant protein, its normal location appears to be cytosolic (Hatzis et al. 1998).

Literature References
PubMed ID Title Journal Year
2844225 Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme

Bohman, C, Eriksson, S

Biochemistry 1988
9804782 The intracellular localization of deoxycytidine kinase

Talianidis, I, Jullig, M, Petrakis, TG, Hatzis, P, Al-Madhoon, AS, Eriksson, S

J Biol Chem 1998
2539852 Human T-lymphoblast deoxycytidine kinase: purification and properties

Datta, NS, Fox, IH, Hurley, MC, Shewach, DS, Mitchell, BS

Biochemistry 1989
Catalyst Activity

nucleoside kinase activity of DCK dimer [cytosol]

Orthologous Events
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