Reactome | (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

Stable Identifier

R-HSA-109624

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

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Cytosolic adenosine kinase (ADK) catalyzes the reactions of adenosine and deoxyadenosine with ATP to yield the corresponding nucleotide monophosphates and ADP (Andres and Fox 1979). The enzyme is substantially more active on adenosine than deoxyadenosine in vitro (Hurley at al. 1985) though studies of cultured cells suggest that both reactions may be physiologically relevant (Hershfield et al. 1982). The enzyme is a monomer complexed with magnesium (Mathews et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9843365	Structure of human adenosine kinase at 1.5 A resolution. Ealick, SE, Mathews, II, Erion, MD	Biochemistry	1998
6281270	Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells Bagnara, AS, Williams, SR, Fetter, JE, Small, WC, Hershfield, MS, Wasson, DB, Carson, DA, Ullman, B, Martin, Jr, DW	J Biol Chem	1982
2999129	Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase Lin, B, Fox, IH, Hurley, MC	J Biol Chem	1985
227870	Purification and properties of human placental adenosine kinase Fox, IH, Andres, CM	J Biol Chem	1979