Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

Stable Identifier
R-HSA-109539
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The plasma membrane-associated protein SLC28A2 mediates the transport of one molecule of adenosine, guanosine, inosine, or uridine, and one sodium ion, from the extracellular space to the cytosol.
Literature References
PubMed ID Title Journal Year
10455109 Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na+ nucleoside cotransporters hCNT1 and hCNT2

Loewen, SK, Ng, AM, Yao, SY, Cass, CE, Baldwin, SA, Young, JD

J Biol Chem 1999
9435697 Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization

Wang, J, Su, SF, Dresser, MJ, Schaner, ME, Washington, CB, Giacomini, KM

Am J Physiol Renal Physiol 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nucleoside:sodium symporter activity of SLC28A2 [plasma membrane]

Physical Entity
SLC28A2 [plasma membrane] (Homo sapiens)
Activity
nucleoside:sodium symporter activity (GO:0005415)
Orthologous Events
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Sus scrofa)
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2004-01-13)
Reviewed
He, L  (2010-05-10)
Created
D'Eustachio, P  (2004-01-13)
Cite Us!