Reactome | CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3

CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3

Stable Identifier

R-HSA-1028817

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Interaction of CBP/p300 with p-IRF3 dimer

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        Evasion by RSV of host interferon responses (Homo sapiens)
        
        CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)

General

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CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3

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Phosphorylated IRF3 dimer translocated to the nucleus and interacts with the coactivator CBP/p300. This interaction prevents the export of activated IRF3 dimer from nucleus. It may also alter the conformation of the DNA binding domain of IRF3 and induce specific DNA binding of IRF3 (Sato et al, 1998; Yoneyama et al, 1998; Lin et al, 1999). The interaction is inhibited by human respiratory syncytial virus (hRSV) non-structural protein NS1, which binds to both IRF3 and CREBBP (Ren et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
10082512	Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains Hiscott, J, Lin, R, Mamane, Y	Mol Cell Biol	1999
21632562	A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein Ren, J, Bao, X, Casola, A, Li, K, Liu, T, Garofalo, RP, Pang, L	J Gen Virol	2011
9541017	Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene Sato, M, Hata, N, Oda, E, Taniguchi, T, Tanaka, N	FEBS Lett	1998
9463386	Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 Nishida, E, Fukuda, M, Suhara, W, Fujita, T, Fukuhara, Y, Yoneyama, M	EMBO J	1998

Participants

Input

Output

p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 [nucleoplasm] (Homo sapiens)

Participates

as an event of

This event is regulated

Negatively by

Regulator

CREBBP:NS1 [nucleoplasm] (Homo sapiens)

Regulator

IRF3:NS1 [nucleoplasm] (Homo sapiens)

Authored

Garapati, P V (2010-08-02)

Reviewed

Bergeron, HC (2023-11-03)

Akira, S (2010-10-30)

Kawai, T (2010-10-30)

Created

Garapati, P V (2010-11-18)

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