CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3

Stable Identifier
R-HSA-1028817
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interaction of CBP/p300 with p-IRF3 dimer
ReviewStatus
5/5
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Phosphorylated IRF3 dimer translocated to the nucleus and interacts with the coactivator CBP/p300. This interaction prevents the export of activated IRF3 dimer from nucleus. It may also alter the conformation of the DNA binding domain of IRF3 and induce specific DNA binding of IRF3 (Sato et al, 1998; Yoneyama et al, 1998; Lin et al, 1999). The interaction is inhibited by human respiratory syncytial virus (hRSV) non-structural protein NS1, which binds to both IRF3 and CREBBP (Ren et al, 2011).
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