Reactome | Rabenosyn-5 connects Rab5 to VPS-45

Rabenosyn-5 connects Rab5 to VPS-45

Stable Identifier

R-HSA-1011600

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

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The small GTPase Rab5 regulates membrane traffic into and between early endosomes by specifically recruiting cytosolic effector proteins to their site of action on early endosomal membranes. Rab5 occupies a restricted membrane subdomain on endosomes that has distinct biochemical features when compared with neighboring subcompartments (Sonnichsen et al. 2000). Rab5 is believed to form this subdomain by recruiting the specific PI3 kinase VPS-45, causing localized production of PI-3-phosphate (PI-3P) (Christoforidis et al. 1999). Rabenosyn-5 is a Rab5 effector, recruited in a phosphatidylinositol-3-kinase dependent fashion to early endosomes where it serves as a molecular link between VPS-45 and Rab5.

Literature References

PubMed ID	Title	Journal	Year
11062261	Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain Nielsen, E, Christoforidis, S, Uttenweiler-Joseph, S, Miaczynska, M, Dewitte, F, Wilm, M, Hoflack, B, Zerial, M	J Cell Biol	2000