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ITCH [cytosol]
Stable Identifier
R-GGA-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
ITCH, A0A8V0ZZH3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX1 (Gallus gallus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Gallus gallus)
ITCH polyubiquitinates TP73 (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Polyubiquitination of substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Release of E3 from polyubiquitinated substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Hedgehog (Gallus gallus)
Hedgehog 'off' state (Gallus gallus)
Degradation of GLI1 by the proteasome (Gallus gallus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB binds ITCH (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Hedgehog 'on' state (Gallus gallus)
NUMB binds ITCH (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH binds GLI1 (Gallus gallus)
GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)
GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI is degraded by the proteasome (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH1 (Gallus gallus)
Activated NOTCH1 Transmits Signal to the Nucleus (Gallus gallus)
ITCH binds DTX (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH ubiquitinates DTX (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Ub-DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
Downregulation of ERBB4 signaling (Gallus gallus)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0ZZH3 ITCH
Gene Names
ITCH
Reference Genes
UCSC:A0A8V0ZZH3 ITCH
Other Identifiers
419145
GO:0000209
GO:0002376
GO:0002669
GO:0002683
GO:0002684
GO:0002753
GO:0002870
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0005938
GO:0006511
GO:0006513
GO:0006915
GO:0006979
GO:0009896
GO:0010468
GO:0010604
GO:0016020
GO:0016192
GO:0016567
GO:0016740
GO:0016874
GO:0030163
GO:0031410
GO:0031623
GO:0031901
GO:0032991
GO:0034450
GO:0035519
GO:0035739
GO:0038160
GO:0039532
GO:0043021
GO:0043066
GO:0043124
GO:0043161
GO:0044389
GO:0045087
GO:0045236
GO:0045732
GO:0046329
GO:0050687
GO:0051241
GO:0051607
GO:0051865
GO:0061630
GO:0070534
GO:0070936
GO:0071944
GO:0090085
GO:0098542
GO:0140096
GO:0141198
GO:1902532
GO:1990763
GO:2000562
GO:2000646
GT_A_87_P018096
GT_A_87_P022209
GT_A_87_P039526
GT_A_87_P070151
GT_A_87_P117343
Gga.10549.1.S1_s_at
Gga.14128.1.S1_at
Gga.9750.1.S1_s_at
GgaAffx.1295.1.S1_s_at
Participates
as an input of
NUMB binds ITCH (Gallus gallus)
ITCH binds DTX (Gallus gallus)
as a component of
NUMB:ITCH [cytosol] (Gallus gallus)
Ub-DTX:ITCH [cytosol] (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Gallus gallus)
as a member of
WWP1/ITCH [cytosol] (Gallus gallus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
Other forms of this molecule
ITCH [cytosol]
Inferred From
ITCH [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALT00010060359
,
ENSGALG00010024723
,
ENSGALP00010037118
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