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ITCH [cytosol]
Stable Identifier
R-GGA-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A1D5PQP3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX1 (Gallus gallus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Gallus gallus)
ITCH polyubiquitinates TP73 (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Polyubiquitination of substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Release of E3 from polyubiquitinated substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Hedgehog (Gallus gallus)
Hedgehog 'off' state (Gallus gallus)
Degradation of GLI1 by the proteasome (Gallus gallus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB binds ITCH (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Hedgehog 'on' state (Gallus gallus)
NUMB binds ITCH (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH binds GLI1 (Gallus gallus)
GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)
GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI is degraded by the proteasome (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ub-GLI1:NUMB:ITCH [cytosol] (Gallus gallus)
NUMB:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH1 (Gallus gallus)
Activated NOTCH1 Transmits Signal to the Nucleus (Gallus gallus)
ITCH binds DTX (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ITCH ubiquitinates DTX (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Ub-DTX:ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
Downregulation of ERBB4 signaling (Gallus gallus)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Gallus gallus)
WWP1/ITCH [cytosol] (Gallus gallus)
ITCH [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5PQP3
Reference Genes
ENSEMBL:ENSGALG00000040474
Participates
as a member of
WWP1/ITCH [cytosol] (Gallus gallus)
as an input of
NUMB binds ITCH (Gallus gallus)
ITCH binds DTX (Gallus gallus)
as a component of
NUMB:ITCH [cytosol] (Gallus gallus)
Ub-DTX:ITCH [cytosol] (Gallus gallus)
DTX:ITCH [cytosol] (Gallus gallus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Gallus gallus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
Inferred From
ITCH [cytosol]
(Homo sapiens)
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