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phospho-p-TYK2 [cytosol]
Stable Identifier
R-GGA-8950424
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A1D5PK82
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by CSF3 (G-CSF) (Gallus gallus)
Inactivation of CSF3 (G-CSF) signaling (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-12 family signaling (Gallus gallus)
Interleukin-35 Signalling (Gallus gallus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Gallus gallus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Gallus gallus)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Gallus gallus)
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
Interleukin-20 family signaling (Gallus gallus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Gallus gallus)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Gallus gallus)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-TYK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5PK82
Reference Genes
ENSEMBL:ENSGALG00000030599
UCSC:A0A1D5PK82
Participates
as a candidate of
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
as a component of
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Gallus gallus)
IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-p-Y-TYK2 [cytosol]
TYK2 [cytosol]
phospho-p-Y1054,Y1055-TYK2 [cytosol]
phospho-p-Y1054-TYK2 [cytosol]
Inferred From
p-TYK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
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