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p-TYK2 [cytosol]
Stable Identifier
R-HSA-8950424
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Homo sapiens)
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Homo sapiens)
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-TYK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29597 TYK2
Gene Names
TYK2
Chain
chain:1-1187
Reference Genes
BioGPS Gene:7297 TYK2
COSMIC - genes:TYK2 TYK2
CTD Gene:7297 TYK2
dbSNP Gene:7297 TYK2
ENSEMBL:ENSG00000105397 TYK2
HGNC:12440 TYK2
KEGG:hsa:7297 TYK2
Monarch:7297 TYK2
NCBI Gene:7297 TYK2
OMIM:176941 TYK2
UCSC:P29597 TYK2
Reference Transcript
RefSeq:NM_003331.4 TYK2
RefSeq:NM_001406461.1 TYK2
Other Identifiers
11757379_a_at
16868689
205546_PM_s_at
205546_s_at
3850279
3850280
3850281
3850282
3850284
3850285
3850288
3850289
3850290
3850291
3850292
3850293
3850294
3850295
3850296
3850298
3850299
3850300
3850301
3850302
3850303
3850304
3850305
3850306
3850307
3850308
3850309
3850310
3850311
3850312
3850313
3850314
3850315
3850316
3850317
3850318
3850319
3850320
3850321
3850322
3850323
3850325
3850326
3850327
3850328
7297
8033996
993_at
A_23_P141917
A_23_P153311
GE59795
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006357
GO:0006468
GO:0006955
GO:0007259
GO:0008283
GO:0009898
GO:0016020
GO:0016301
GO:0016740
GO:0019221
GO:0019897
GO:0022407
GO:0030154
GO:0031234
GO:0032729
GO:0032740
GO:0032819
GO:0035556
GO:0035722
GO:0038155
GO:0038196
GO:0042022
GO:0042102
GO:0043235
GO:0046425
GO:0046427
GO:0046634
GO:0051142
GO:0051239
GO:0060333
GO:0060337
GO:0060397
GO:0070062
GO:0072536
GO:0098586
GO:0140096
GO:0140105
GO:1900182
GO:2000318
HMNXSV003025674
ILMN_1676955
PH_hs_0004337
TC19001164.hg
X54637_at
g4507748_3p_a_at
Participates
as a candidate of
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Homo sapiens)
as a member of
p-JAK1:p-JAK2:p-TYK2 [cytosol] (Homo sapiens)
as a component of
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y1054-TYK2 [cytosol]
p-Y1054,Y1055-TYK2 [cytosol]
TYK2 [cytosol]
p-Y-TYK2 [cytosol]
Inferred To
phospho-TYK2 [cytosol]
(Canis familiaris)
phospho-p-TYK2 [cytosol]
(Bos taurus)
phospho-p-TYK2 [cytosol]
(Danio rerio)
phospho-p-TYK2 [cytosol]
(Gallus gallus)
phospho-p-TYK2 [cytosol]
(Mus musculus)
phospho-p-TYK2 [cytosol]
(Rattus norvegicus)
phospho-p-TYK2 [cytosol]
(Sus scrofa)
phospho-p-TYK2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_003322.3
,
NP_001393390.1
ZINC - World Drugs
TYK2_HUMAN
Guide to Pharmacology - Targets
2269
OpenTargets
ENSG00000105397
ENSEMBL
ENST00000531836
,
ENST00000525621
,
ENSP00000436175
,
ENSG00000105397
,
ENSP00000431885
ZINC - FDA approved
TYK2_HUMAN
ZINC - Substances
TYK2_HUMAN
ZINC - Biogenic
TYK2_HUMAN
ZINC target
P29597
PRO
P29597
GlyGen
P29597
PDB
6NZE
,
5F20
,
6VNX
,
5C03
,
3LXP
,
6VNV
,
6VNS
,
8EYC
,
5TKD
,
3NZ0
,
8TB5
,
6OVA
,
4GJ3
,
4GII
,
8S99
,
7K7Q
,
7UYR
,
6X8F
,
7UYT
,
7UYU
,
4PO6
,
6NZR
,
6NZH
,
6NZQ
,
6NZF
,
8S9A
,
3LXN
,
5F1Z
,
6AAM
,
5C01
,
3ZON
,
6VNY
,
6NSL
,
3NYX
,
4OLI
,
8TB6
,
4WOV
,
7AX4
,
4GJ2
,
8EXN
,
8S98
,
6X8G
,
5WAL
,
4GIH
,
7K7O
,
4GFO
,
6DBK
,
7UYS
,
6DBM
,
4PY1
,
4GVJ
,
6NZP
ZINC - Investigational
TYK2_HUMAN
IntEnz
2.7.10.2
GeneCards
TYK2
HPA
ENSG00000105397-TYK2
Pharos - Targets
P29597
Orphanet
TYK2
ZINC - Predictions - Purchasable
TYK2_HUMAN
HMDB Protein
HMDBP01375
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.781
7
UniProt:Q13643 FHL3
0.718
6
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.666
4
UniProt:Q96FV0 LRC46
0.643
3
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.641
4
UniProt:P17181 IFNAR1
2
p-Y466,Y481-IFNAR1 [plasma membrane]
(R-HSA-909675)
IFNAR1 [plasma membrane]
(R-HSA-877334)
0.564
2
UniProt:P17181-1 IFNAR1
0.558
3
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.556
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:O95994 AGR2
0.556
5
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:Q9NQX1-2 PRDM5
0.556
3
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:P24394 IL4R
2
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
IL4R [plasma membrane]
(R-HSA-449670)
0.527
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:Q96FT9 IFT43
2
IFT43 [cilium]
(R-HSA-5617619)
IFT43 [ciliary tip]
(R-HSA-5625348)
0.527
2
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
UniProt:Q8IYS4 DAAF8
0.527
2
UniProt:O43567 RNF13
0.527
3
UniProt:Q8NFN8 GP156
0.527
2
UniProt:O14836 TNFRSF13B
1
TAC1 [plasma membrane]
(R-HSA-5668752)
0.527
2
UniProt:P55286 CDH8
1
CDH8 [plasma membrane]
(R-HSA-419000)
0.527
2
UniProt:P52799 EFNB2
2
p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(R-HSA-3928387)
EFNB2 [plasma membrane]
(R-HSA-2682330)
0.527
2
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.527
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.524
2
UniProt:P04019 VE6
0.524
3
UniProt:P06463 VE6
0.524
4
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