Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-GGA-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A8V0YLV1

Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - MAP2K and MAPK activation (Gallus gallus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        MAP2Ks phosphorylate MAPKs (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        RAF phosphorylates MAP2K dimer (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Gallus gallus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
        
        RAF/MAPK scaffolds [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
      - Negative regulation of MAPK pathway (Gallus gallus)
        
        BRAP binds KSR1:MARK3 (Gallus gallus)
        
        BRAP:KSR1:MARK3 [cytosol] (Gallus gallus)
        
        KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
      - RAF activation (Gallus gallus)
        
        MARK3 phosphorylates KSR1 (Gallus gallus)
        
        KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        Phosphorylation of RAF (Gallus gallus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
        
        activated RAF/KSR1 [plasma membrane] (Gallus gallus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)
        
        BRAP:KSR1:MARK3 [cytosol] (Gallus gallus)
        
        KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Gallus gallus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        YWHAB dimer dissociates from KSR1:MARK3 (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Gallus gallus)
        
        p-S311 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Gallus gallus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Gallus gallus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Gallus gallus)
        
        MARK3 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0YLV1

Reference Genes

ENSEMBL:ENSGALG00010015792.1

UCSC:A0A8V0YLV1

Other Identifiers

423480

GO:0000166

GO:0000226

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005737

GO:0005886

GO:0006468

GO:0007010

GO:0010389

GO:0016301

GO:0016740

GO:0019903

GO:0030425

GO:0035331

GO:0035556

GO:0042995

GO:0050321

GO:0140096

GO:1900181

GT_A_87_P015169

GT_A_87_P085821

GT_A_87_P126808

GT_A_87_P264358

GT_A_87_P268728

Gga.17127.1.S1_at

Gga.19345.1.S1_at

Participates

as a component of

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010038013, ENSGALG00010015792, ENSGALP00010021932

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