TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Stable Identifier
R-GGA-434001
Type
Pathway
Species
Gallus gallus
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Click the image above or here to open this pathway in the Pathway Browser
NF-kappa-B is sequestered in the cytoplasm in a complex with inhibitor of NF-kappa-B (IkB). Almost all NF-kappa-B activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappa-B from the complex. This allows translocation of NF-kappa-B to the nucleus where it regulates gene expression.
Literature References
PubMed ID Title Journal Year
16056267 Ubiquitin signalling in the NF-kappaB pathway

Chen, ZJ

Nat Cell Biol 2005
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
1533881 p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells

Capobianco, AJ, Chang, D, Mosialos, G, Gilmore, TD

J Virol 1992
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
activation of NF-kappaB-inducing kinase activity (0007250)
Inferred From
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-08-27)
Cite Us!