TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Stable Identifier
R-GGA-434001
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Pathway
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Gallus gallus
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression.

Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
16056267 Ubiquitin signalling in the NF-kappaB pathway

Chen, ZJ

Nat Cell Biol 2005
1533881 p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells

Capobianco, AJ, Chang, D, Mosialos, G, Gilmore, TD

J Virol 1992
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activation of NF-kappaB-inducing kinase activity (0007250)
Inferred From
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-08-27)
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