adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate

Stable Identifier
R-GGA-421197
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate
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Cytosolic ADSL catalyzes the cleavage of adenylosuccinate to form AMP and fumarate. The chicken ADSL gene has been cloned (Aimi et al. 1990) but its protein product has not been biochemically characterized and this reaction is inferred from its better-studied human counterpart.
Literature References
PubMed ID Title Journal Year
2111814 Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli

Aimi, J, Badylak, J, Williams, J, Chen, ZD, Zalkin, H, Dixon, JE

J Biol Chem 1990
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Catalyst Activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity of ADSL [cytosol]

Physical Entity
ADSL [cytosol] (Gallus gallus)
Activity
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity (GO:0004018)
Inferred From
adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)
Authored
D'Eustachio, P  (2009-05-15)
Created
D'Eustachio, P  (2009-05-16)
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