adenylosuccinate => adenosine 5'-monophosphate + fumarate

Stable Identifier
R-HSA-73828
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Adenylosuccinate => AMP + Fumarate
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The irreversible conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993). The enzyme also catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).

Literature References
PubMed ID Title Journal Year
8366112 Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase

Zalkin, H, Stone, RL, Dixon, JE

J Biol Chem 1993
Participants
Participates
Catalyst Activity

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity of ADSL tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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