Sfks phosphorylate EfnB1

Stable Identifier
R-GGA-3928593
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sfks phosphorylate EfnB1
The Src-family kinases (SFKs) SRC and FYN, colocalised with ephrinBs (EFNBs) at the membrane, are required for EFNB phosphorylation. The cytoplasmic domains of all three EFNBs consist of five conserved tyrosine residues of which three undergo phosphorylation. Electrospray tandem mass spectrometry and site-directed mutagenesis identified tyrosines 312, 317, and 331 (human 324, 329 and 343) of EFNB1 as phosphorylation sites (Kalo et al. 2001, Palmer et al. 2002).
Literature References
PubMed ID Title Journal Year
11983165 EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

Klein, R, Zimmer, M, Deutsch, U, Eulenburg, V, Porthin, A, Palmer, A, Heumann, R, Erdmann, KS

Mol. Cell 2002
11466320 In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue

Yu, HH, Pasquale, EB, Kalo, MS

J. Biol. Chem. 2001
9054357 Tyrosine phosphorylation of transmembrane ligands for Eph receptors

Brückner, K, Klein, R, Pasquale, EB

Science 1997
8878483 Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

Henkemeyer, M, Gale, NW, Yancopoulos, GD, Mbamalu, G, Holland, SJ, Pawson, T

Nature 1996
Participants
Input
Output
Entity On Other Cell
Catalyst Activity

protein tyrosine kinase activity of Src [cytosol]

Physical Entity
Src [cytosol] (Gallus gallus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SFKs phosphorylate EFNBs (Homo sapiens)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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