Sfks phosphorylate EfnB1

Stable Identifier
Reaction [transition]
Gallus gallus
SVG |   | PPTX  | SBGN
Sfks phosphorylate EfnB1

The Src-family kinases (SFKs) SRC and FYN, colocalised with ephrinBs (EFNBs) at the membrane, are required for EFNB phosphorylation. The cytoplasmic domains of all three EFNBs consist of five conserved tyrosine residues of which three undergo phosphorylation. Electrospray tandem mass spectrometry and site-directed mutagenesis identified tyrosines 312, 317, and 331 (human 324, 329 and 343) of EFNB1 as phosphorylation sites (Kalo et al. 2001, Palmer et al. 2002).

Literature References
PubMed ID Title Journal Year
9054357 Tyrosine phosphorylation of transmembrane ligands for Eph receptors

Br├╝ckner, K, Klein, R, Pasquale, EB

Science 1997
11983165 EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

Klein, R, Zimmer, M, Deutsch, U, Eulenburg, V, Porthin, A, Palmer, A, Heumann, R, Erdmann, KS

Mol. Cell 2002
8878483 Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

Henkemeyer, M, Gale, NW, Yancopoulos, GD, Mbamalu, G, Holland, SJ, Pawson, T

Nature 1996
11466320 In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue

Yu, HH, Pasquale, EB, Kalo, MS

J. Biol. Chem. 2001
Catalyst Activity

protein tyrosine kinase activity of Src [cytosol]

Orthologous Events
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