SFKs phosphorylate EFNBs

Stable Identifier
R-HSA-3928580
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The Src-family kinases (SFKs) SRC and FYN, colocalised with ephrinBs (EFNBs) at the membrane, are required for EFNB phosphorylation. The cytoplasmic domains of all three EFNBs consist of five conserved tyrosine residues of which three undergo phosphorylation. Electrospray tandem mass spectrometry and site-directed mutagenesis identified tyrosines 312, 317, and 331 (human 324, 329 and 343) of EFNB1 as phosphorylation sites (Kalo et al. 2001, Palmer et al. 2002).

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPHBs:EFNBs:SRC,FYN [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created