Reactome | PRKAG1 [cytosol]

PRKAG1 [cytosol]

Stable Identifier

R-GGA-380946

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

PRKAG1, A0A8V0ZTT9

Locations in the PathwayBrowser

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Autophagy (Gallus gallus)

- Macroautophagy (Gallus gallus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - Thr-180 of ULK1 is phosphorylated (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - ULK complex translocates to the ER (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates Beclin-1 (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - p-AMPK:AMP binds the ULK complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional Regulation by TP53 (Gallus gallus)
      - TP53 Regulates Metabolic Genes (Gallus gallus)
        
        SESN1,2,3 bind AMPK (Gallus gallus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Gallus gallus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZTT9

Gene Names

PRKAG1

Reference Genes

ENSEMBL:ENSGALG00010024650.1

UCSC:A0A8V0ZTT9 PRKAG1

Other Identifiers

429688

GO:0005634

GO:0005737

GO:0006110

GO:0006629

GO:0006633

GO:0006913

GO:0016208

GO:0016301

GO:0019887

GO:0019901

GO:0031588

GO:0031669

GO:0042149

GO:0043609

GO:0045722

GO:0051170

GT_A_87_P052146

GT_Sp_Chicken_CN223775_4182

Participates

as a member of

AMPK gamma [cytosol] (Gallus gallus)

Other forms of this molecule

PRKAG1 [endoplasmic reticulum lumen]

Inferred From

PRKAG1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSGALG00010024650, ENSGALP00010036945, ENSGALT00010060185

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