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USP7 [nucleoplasm]
Stable Identifier
R-GGA-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
USP7, A0A8V0Z5X3
Locations in the PathwayBrowser
Expand all
DNA Repair (Gallus gallus)
Nucleotide Excision Repair (Gallus gallus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
Dual incision in TC-NER (Gallus gallus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)
TC-NER incision complex [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
ERCC5 and RPA bind TC-NER site (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Formation of TC-NER Pre-Incision Complex (Gallus gallus)
Assembly of the pre-incision complex in TC-NER (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Gallus gallus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
Regulation of TP53 Activity (Gallus gallus)
Regulation of TP53 Expression and Degradation (Gallus gallus)
Regulation of TP53 Degradation (Gallus gallus)
DAXX binds Ub-MDM2 and USP7 (Gallus gallus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
USP7 deubiquitinates MDM2 (Gallus gallus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN localization (Gallus gallus)
USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)
USP7 [nucleoplasm] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0Z5X3
Gene Names
USP7
Reference Genes
BioGPS Gene:395126 USP7
ENSEMBL:ENSGALG00010018419.1
Monarch:395126 USP7
NCBI Gene:395126 USP7
UCSC:A0A8V0Z5X3 USP7
Reference Transcript
RefSeq:XM_040647310.2 USP7
Other Identifiers
395126
GO:0000045
GO:0002039
GO:0004197
GO:0004843
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0006281
GO:0006283
GO:0006307
GO:0006325
GO:0006508
GO:0008233
GO:0008234
GO:0010507
GO:0010508
GO:0016579
GO:0016605
GO:0016787
GO:0031647
GO:0031669
GO:0032435
GO:0032991
GO:0035520
GO:0038202
GO:0042752
GO:0044027
GO:0045721
GO:0050821
GO:0070203
GO:0075342
GO:0101005
GO:1904262
GO:1905279
GO:1990380
GT_A_87_P035183
GT_A_87_P117443
Gga.9341.1.S1_at
Gga.9341.1.S2_at
Gga.9341.3.S1_a_at
Gga.9341.4.S1_a_at
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Gallus gallus)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Gallus gallus)
UVSSA:USP7 [nucleoplasm] (Gallus gallus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Gallus gallus)
as an output of
USP7 deubiquitinates MDM2 (Gallus gallus)
as an input of
DAXX binds Ub-MDM2 and USP7 (Gallus gallus)
Other forms of this molecule
USP7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_040503244.2
ENSEMBL
ENSGALT00010044600
,
ENSGALG00010018419
,
ENSGALP00010026550
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