Reactome | Factor H binds to C3b

Factor H binds to C3b

Stable Identifier

R-HSA-976768

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Factor H (CFH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. FH binds to plasma C3b, making it unavailable, and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References

PubMed ID	Title	Journal	Year
1067618	Control of the amplification convertase of complement by the plasma protein beta1H Weiler, JM, Fearon, DT, Daha, MR, Austen, KF	Proc Natl Acad Sci U S A	1976
301546	Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution Schreiber, RD, Pangburn, MK, Muller-Eberhard, HJ	J Exp Med	1977