Factor H binds to C3b

Stable Identifier
R-HSA-976768
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Factor H (CFH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. FH binds to plasma C3b, making it unavailable, and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References
PubMed ID Title Journal Year
301546 Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

Pangburn, MK, Schreiber, RD, Muller-Eberhard, HJ

J Exp Med 1977
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Daha, MR, Austen, KF, Fearon, DT

Proc Natl Acad Sci U S A 1976
Participants
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Orthologous Events
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