Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EZH2 [nucleoplasm]
Stable Identifier
R-GGA-212298
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
EZH2, A0A8V0Y617
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Gallus gallus)
Cell junction organization (Gallus gallus)
Cell-cell junction organization (Gallus gallus)
Adherens junctions interactions (Gallus gallus)
Regulation of Homotypic Cell-Cell Adhesion (Gallus gallus)
Regulation of Expression and Function of Type I Classical Cadherins (Gallus gallus)
Regulation of CDH1 Expression and Function (Gallus gallus)
Regulation of CDH1 Gene Transcription (Gallus gallus)
Negative Regulation of CDH1 Gene Transcription (Gallus gallus)
PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular Senescence (Gallus gallus)
Oxidative Stress Induced Senescence (Gallus gallus)
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
Epigenetic regulation of gene expression (Gallus gallus)
PRC2 methylates histones and DNA (Gallus gallus)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Gallus gallus)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 Core:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 recruits DNA methyltransferases (Gallus gallus)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 Core:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 Core:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
EZHIP:PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:JARID2:MTF2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF1 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF19 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Gallus gallus)
PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:JARID2:MTF2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF1 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF19 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:JARID2:MTF2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF1 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF19 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)
EPOP:PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH1,EZH2) core [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:JARID2:MTF2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF1 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF19 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:Chromatin [nucleoplasm] (Gallus gallus)
PRC2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:JARID2:MTF2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF1 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2:PHF19 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by E2F6 (Gallus gallus)
E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)
E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-inhibition by PD-1 (Gallus gallus)
Regulation of PD-L1(CD274) expression (Gallus gallus)
Regulation of PD-L1(CD274) transcription (Gallus gallus)
Trimethylation of CD274 gene promoter by EZH2 (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN gene transcription (Gallus gallus)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Gallus gallus)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Gallus gallus)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
EZH2 [nucleoplasm] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0Y617
Gene Names
EZH2
Reference Genes
BioGPS Gene:420784 EZH2
ENSEMBL:ENSGALG00010008330.1
Monarch:420784 EZH2
NCBI Gene:420784 EZH2
UCSC:A0A8V0Y617 EZH2
Reference Transcript
RefSeq:XM_040664523.2 EZH2
RefSeq:XM_015275908.4 EZH2
Other Identifiers
420784
GO:0000082
GO:0000122
GO:0000781
GO:0000785
GO:0000978
GO:0000979
GO:0001222
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005721
GO:0006325
GO:0006338
GO:0006346
GO:0006355
GO:0006357
GO:0008168
GO:0008284
GO:0009913
GO:0010468
GO:0010718
GO:0014013
GO:0014834
GO:0014898
GO:0016279
GO:0016740
GO:0021695
GO:0030097
GO:0030154
GO:0030183
GO:0030216
GO:0030335
GO:0031047
GO:0031048
GO:0031490
GO:0031491
GO:0031507
GO:0031509
GO:0032259
GO:0034244
GO:0035098
GO:0035984
GO:0036333
GO:0042054
GO:0042127
GO:0042393
GO:0042752
GO:0043021
GO:0043565
GO:0045120
GO:0045605
GO:0045617
GO:0045814
GO:0045892
GO:0046976
GO:0048387
GO:0048511
GO:0048856
GO:0048863
GO:0050767
GO:0051154
GO:0070301
GO:0070314
GO:0070878
GO:0071168
GO:0097421
GO:0106222
GO:0140096
GO:0140718
GO:1902808
GO:1904772
GO:1990841
GO:2000134
GO:2000737
GT_A_87_P012601
GT_A_87_P102686
GT_A_87_P216493
GT_A_87_P262318
Gga.20057.1.S1_s_at
Gga.4473.1.S1_at
GgaAffx.23895.1.S1_at
Participates
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Gallus gallus)
Inferred From
EZH2 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALG00010008330
,
ENSGALT00010019926
,
ENSGALP00010011474
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text