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phospho-p-6Y-SYK [cytosol]
Stable Identifier
R-GGA-1861712
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1N9Y5
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
BLNK (SLP-65) Signalosome [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
BTK binds BTK inhibitors (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
BTK:BTK inhibitors [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
SYK autophosphorylates at the activated BCR (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
SYK/LCK/ZAP-70 [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation of BTK by p-SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
SYK/LCK/ZAP-70 [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
p-SYK,p-BTK [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
p-SYK/p-BTK [plasma membrane] (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
SYK/LCK/ZAP-70 [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation of SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Activation of RAC1 by VAV (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation of VAV (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K binds to p-6Y-SYK (Gallus gallus)
PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Phosphorylation and activation of PLCG (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Recruitment of PLCgamma to membrane (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
Release of PLCG from FCGR (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
phospho-p-6Y-SYK [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1N9Y5 SYK
Gene Names
SYK, RCJMB04_19o18
Chain
chain:1-613
Reference Genes
BioGPS Gene:427272 SYK
ENSEMBL:ENSGALG00000015216 SYK
ENSEMBL:ENSGALG00010009340.1 SYK
ENSEMBL:ENSGALG00015028988 SYK
KEGG Gene (Gallus gallus):427272 SYK
Monarch:427272 SYK
NCBI Gene:427272 SYK
Reference Transcript
RefSeq:NM_001031430.1 SYK
Other Identifiers
427272
GO:0000166
GO:0001945
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006954
GO:0007155
GO:0007159
GO:0007169
GO:0007229
GO:0010543
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0023052
GO:0030154
GO:0030593
GO:0031234
GO:0031410
GO:0032009
GO:0032928
GO:0033630
GO:0035556
GO:0036211
GO:0042060
GO:0042742
GO:0043226
GO:0043306
GO:0043313
GO:0045087
GO:0045579
GO:0045780
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050764
GO:0050853
GO:0070301
GO:0070372
GO:0071226
GO:0090237
GO:0090330
GO:0098542
GO:0140096
GT_A_87_P092781
GgaAffx.12646.1.S1_at
GgaAffx.9684.1.S1_s_at
Participates
as a member of
p-SYK,p-BTK [cytosol] (Gallus gallus)
SYK/LCK/ZAP-70 [cytosol] (Gallus gallus)
as a component of
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-p-Y-SYK [cytosol]
phospho-p-Y-SYK [plasma membrane]
SYK [plasma membrane]
phospho-p-Y348-SYK [cytosol]
SYK [cytosol]
Inferred From
p-6Y-SYK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348 (in Homo sapiens)
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 352 (in Homo sapiens)
Coordinate
352
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 525 (in Homo sapiens)
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 526 (in Homo sapiens)
Coordinate
526
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 131 (in Homo sapiens)
Coordinate
131
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 323 (in Homo sapiens)
Coordinate
323
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001026601.1
OpenTargets
ENSG00000165025
Ensembl
ENSGALP00010012784
,
ENSGALG00010009340
,
ENSGALT00010022248
PRO
F1N9Y5
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