Reactome | EGF [extracellular region]

EGF [extracellular region]

Stable Identifier

R-GGA-179863

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

extracellular region

Synonyms

EGF, A0A8V0XLN7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - Negative regulation of the PI3K/AKT network (Gallus gallus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
        
        PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        Activator:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
      - Activator:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
- Signaling by NOTCH (Gallus gallus)
  - Signaling by NOTCH3 (Gallus gallus)
    - NOTCH3 Activation and Transmission of Signal to the Nucleus (Gallus gallus)
      - EGFR phosphorylates NOTCH3 (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - NOTCH3 binds activated EGFR (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by EGFR (Gallus gallus)
    - EGFR autophosphorylation (Gallus gallus)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGFR:EGF-like ligands [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - EGFR binds EGF ligand (Gallus gallus)
      - EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGFR:EGF-like ligands [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - EGFR dimerization (Gallus gallus)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGFR:EGF-like ligands [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGFR:EGF-like ligands [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - EGFR downregulation (Gallus gallus)
      - Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Binding of CBL to EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - CBL ubiquitinates Sprouty (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - CBL-mediated ubiquitination of CIN85 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGFR phosphorylates EPS15 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Localization of CBL:GRB2 to the membrane (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)
        
        EGF:p-6Y-EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148) [plasma membrane] (Gallus gallus)
        
        EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PTPN3 dephosphorylates EPS15 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Sprouty sequesters CBL away from active EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - EGFR interacts with phospholipase C-gamma (Gallus gallus)
      - Active PLC-gamma1 dissociates from EGFR (Gallus gallus)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - GAB1 signalosome (Gallus gallus)
      - Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Dephosphorylation of PAG by SHP2 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - GAB1 phosphorylation by EGFR kinase (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Phospho-EGFR (-Y1016) dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Sustained activation of SRC kinase by SHP2 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - GRB2 events in EGFR signaling (Gallus gallus)
      - GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Phosphorylation of EGFR by SRC kinase (Gallus gallus)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGFR:EGF-like ligands [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - SHC1 events in EGFR signaling (Gallus gallus)
      - GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
  - Signaling by ERBB2 (Gallus gallus)
    - Downregulation of ERBB2 signaling (Gallus gallus)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Gallus gallus)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - ERBB2 Regulates Cell Motility (Gallus gallus)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - PI3K events in ERBB2 signaling (Gallus gallus)
      - Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
        
        EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - SHC1 events in ERBB2 signaling (Gallus gallus)
      - SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - SRC family kinases phosphorylate ERBB2 (Gallus gallus)
      - ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:EGFR:ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
      - ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:EGFR:ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:p-6Y-EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Gallus gallus)
        
        EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
  - Signaling by ERBB4 (Gallus gallus)
    - ERBB4 forms heterodimers with EGFR (Gallus gallus)
      - EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - ERBB4:EGFR heterodimer [plasma membrane] (Gallus gallus)
        
        EGF:EGFR [plasma membrane] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        EGF [extracellular region] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0XLN7

Gene Names

EGF

Reference Genes

BioGPS Gene:408035 EGF

ENSEMBL:ENSGALG00010003806.1

KEGG:gga:408035 EGF

Monarch:408035 EGF

NCBI Gene:408035 EGF

UCSC:A0A8V0XLN7 EGF

Reference Transcript

RefSeq:NM_001001292.2 EGF

Other Identifiers

408035

GO:0001525

GO:0001938

GO:0002092

GO:0005085

GO:0005154

GO:0005509

GO:0005615

GO:0005886

GO:0006355

GO:0006511

GO:0007173

GO:0008083

GO:0008283

GO:0008284

GO:0010595

GO:0010604

GO:0010628

GO:0016020

GO:0016567

GO:0021930

GO:0021940

GO:0030297

GO:0030335

GO:0038134

GO:0042059

GO:0042327

GO:0043410

GO:0045840

GO:0045893

GO:0046425

GO:0048018

GO:0048731

GO:0048754

GO:0048856

GO:0050673

GO:0050679

GO:0051048

GO:0051049

GO:0051897

GO:0070062

GO:0070086

GO:0070371

GO:0080090

GO:0090263

GO:0090279

GO:0090370

GO:0098772

GO:1900127

GO:1902966

GO:1905278

GO:2000008

GO:2000060

GT_A_87_P035117

GT_Sp_Chicken_CN224899_4740

Gga.17682.1.S1_at

Participates

as a component of

as a member of

EGF-like ligands [extracellular region] (Gallus gallus)

Other forms of this molecule

EGF [clathrin-coated endocytic vesicle membrane]

EGF [extracellular region]

EGF [platelet alpha granule lumen]

Inferred From

EGF [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001001292.2

ENSEMBL

ENSGALP00010005154, ENSGALG00010003806, ENSGALT00010008810

Cite Us!