Reactome | CD4 [plasma membrane]

CD4 [plasma membrane]

Stable Identifier

R-GGA-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

CD4, A0A8V0ZMH6

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - AP-2 directly binds some endocytic cargo (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 cargo [plasma membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)
        
        CD4 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZMH6

Gene Names

CD4

Reference Genes

ENSEMBL:ENSGALG00010023331.1

UCSC:A0A8V0ZMH6 CD4

Other Identifiers

395362

GO:0016020

GT_A_87_P035148

GT_A_87_P058721

Gga.173.1.S1_at

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Gallus gallus)

Other forms of this molecule

CD4 [clathrin-coated endocytic vesicle membrane]

Inferred From

CD4 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSGALG00010023331, ENSGALT00010056881, ENSGALP00010034589

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