Reactome | HGF [extracellular region]

HGF [extracellular region]

Stable Identifier

R-GGA-141767

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

extracellular region

Synonyms

HGF(495-728), A0A8V0Y9C1

Locations in the PathwayBrowser

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Hemostasis (Gallus gallus)

- Platelet activation, signaling and aggregation (Gallus gallus)
  - Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
    - Platelet degranulation (Gallus gallus)
      - Exocytosis of platelet alpha granule contents (Gallus gallus)
        
        Platelet alpha granule contents [extracellular region] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - Negative regulation of the PI3K/AKT network (Gallus gallus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
        
        PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        Activator:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
      - Activator:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by MET (Gallus gallus)
    - MET Receptor Activation (Gallus gallus)
      - HGF dimer binds MET (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET dimers autophosphorylate (Gallus gallus)
        
        HGF:MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MET dimer:TKIs [plasma membrane] (Gallus gallus)
        
        HGF:MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET receptor dimerizes (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET activates PI3K/AKT signaling (Gallus gallus)
      - Activated MET binds GAB1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - Activated MET binds GAB1 and GRB2 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET bound PI3K generates PIP3 (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET phosphorylates GAB1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET activates PTPN11 (Gallus gallus)
      - GAB1 binds PTPN11 (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET activates RAS signaling (Gallus gallus)
      - Activated MET binds RANBP9 and SOS1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - Activated MET recruits GRB2-1:SOS1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET binds RANBP10 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET binds SHC1-2 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET phosphorylates SHC1-2 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET activates STAT3 (Gallus gallus)
      - MET phosphorylates STAT3 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - STAT3 binds activated MET receptor (Gallus gallus)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET promotes cell motility (Gallus gallus)
      - MET activates PTK2 signaling (Gallus gallus)
        
        MET phosphorylates PTK2 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        SRC phosphorylates PTK2 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET activates RAP1 and RAC1 (Gallus gallus)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        DOCK7 activates RAC1 (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        GAB1 recruits CRK,CRKL to MET (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        RAPGEF1 activates RAP1 (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        RAPGEF1 binds CRK,CRKL (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET interacts with TNS proteins (Gallus gallus)
        
        MET binds TNS3 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        MET binds TNS4 (Gallus gallus)
        
        HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - MET receptor recycling (Gallus gallus)
      - GGA3 associates with activated MET receptor (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
    - Negative regulation of MET activity (Gallus gallus)
      - CBL binds MET (Gallus gallus)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - CBL monoubiquitinates activated MET (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - Drug-mediated inhibition of MET activation (Gallus gallus)
        
        Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)
        
        HGF:MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MET dimer:TKIs [plasma membrane] (Gallus gallus)
        
        HGF:MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - EPS15 and HGS bind ubiquitinated MET (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - MET phosphorylates CBL (Gallus gallus)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Gallus gallus)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Gallus gallus)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
      - PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
        
        HGF:p-Y,1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Gallus gallus)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Gallus gallus)
        
        HGF dimer [extracellular region] (Gallus gallus)
        
        HGF [extracellular region] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0Y9C1

Gene Names

HGF

Reference Genes

BioGPS Gene:395941 HGF

ENSEMBL:ENSGALG00010010439.1

KEGG:gga:395941 HGF

Monarch:395941 HGF

NCBI Gene:395941 HGF

UCSC:A0A8V0Y9C1 HGF

Reference Transcript

RefSeq:NM_001030370.5 HGF

Other Identifiers

395941

GO:0000902

GO:0001889

GO:0004252

GO:0005102

GO:0005576

GO:0005615

GO:0006508

GO:0007165

GO:0008083

GO:0014856

GO:0016787

GO:0022603

GO:0030335

GO:0032715

GO:0032733

GO:0035729

GO:0042056

GO:0042802

GO:0043066

GO:0043410

GO:0048012

GO:0048018

GO:0048513

GO:0048856

GO:0048870

GO:0050673

GO:0050728

GO:0050918

GO:0051239

GO:0051450

GO:0051897

GO:0060326

GO:0060665

GO:0090201

GO:0098772

GO:1900744

GO:1901299

GO:1902042

GO:2000573

GT_A_87_P105803

GT_A_87_P105808

Gga.554.1.S1_at

Participates

as a component of

HGF dimer [extracellular region] (Gallus gallus)

Other forms of this molecule

HGF [platelet alpha granule lumen]

HGF [extracellular region]

Inferred From

HGF(495-728) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001025541.3

ENSEMBL

ENSGALT00010024987, ENSGALP00010014196, ENSGALG00010010439

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