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F2 [extracellular region]
Stable Identifier
R-GGA-140589
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
F2(364-622), A0A8V0ZY87
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Coagulation pathway (Gallus gallus)
Amplification and propagation of coagulation cascade (Gallus gallus)
factor V -> factor Va + factor V activation peptide (thrombin catalyst) (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Fibrin formation (Gallus gallus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Initiation of coagulation cascade (Gallus gallus)
factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
factor Va intermediate -> factor Va (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Regulation of clotting cascade (Gallus gallus)
Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide) bind IIa (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Thrombin signalling through proteinase activated receptors (PARs) (Gallus gallus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Complement cascade (Gallus gallus)
Regulation of Complement cascade (Gallus gallus)
Thrombin, ELANE cleave C5 (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (q) signalling events (Gallus gallus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Peptide ligand-binding receptors (Gallus gallus)
Proteinase-activated receptors can bind thrombin (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
F2 [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0ZY87
Gene Names
F2
Reference Genes
ENSEMBL:ENSGALG00010022987.1
UCSC:A0A8V0ZY87 F2
Other Identifiers
395306
GO:0004252
GO:0005509
GO:0005576
GO:0005615
GO:0006508
GO:0006953
GO:0006954
GO:0007596
GO:0008233
GO:0008236
GO:0016787
GO:0030168
GO:0030194
GT_A_87_P009292
Gga.4117.1.S1_at
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [plasma membrane]
F2 [plasma membrane]
F2 [extracellular region]
F2 [extracellular region]
F2 [extracellular region]
Inferred From
F2(364-622) [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALP00010033864
,
ENSGALG00010022987
,
ENSGALT00010055957
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