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itchb [cytosol]
Stable Identifier
R-DRE-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
ITCH, U6C7R6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional regulation by RUNX1 (Danio rerio)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Danio rerio)
ITCH polyubiquitinates TP73 (Danio rerio)
itchb [cytosol] (Danio rerio)
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Polyubiquitination of substrate (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Release of E3 from polyubiquitinated substrate (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Danio rerio)
NOD1/2 Signaling Pathway (Danio rerio)
RIP2 is K63 polyubiquitinated (Danio rerio)
RIP2 ubiquitin ligases [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Hedgehog (Danio rerio)
Hedgehog 'off' state (Danio rerio)
Degradation of GLI1 by the proteasome (Danio rerio)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)
NUMB:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Danio rerio)
NUMB:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
NUMB binds ITCH (Danio rerio)
NUMB:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Hedgehog 'on' state (Danio rerio)
NUMB binds ITCH (Danio rerio)
NUMB:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Signaling by NOTCH (Danio rerio)
Signaling by NOTCH1 (Danio rerio)
Activated NOTCH1 Transmits Signal to the Nucleus (Danio rerio)
ITCH binds DTX (Danio rerio)
DTX:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
ITCH ubiquitinates DTX (Danio rerio)
DTX:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Ub-DTX:ITCH [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB4 (Danio rerio)
Downregulation of ERBB4 signaling (Danio rerio)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Danio rerio)
itchb [cytosol] (Danio rerio)
itchb [cytosol] (Danio rerio)
ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Danio rerio)
itchb [cytosol] (Danio rerio)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Danio rerio)
itchb [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:U6C7R6
Gene Names
itchb
Reference Genes
BioGPS Gene:100330031 itchb
CTD Gene:100330031 itchb
ENSEMBL:ENSDARG00000099199
KEGG Gene (Danio rerio):100330031 itchb
Monarch:100330031 itchb
NCBI Gene:100330031 itchb
Reference Transcript
RefSeq:NM_001302226.1 itchb
Participates
as a component of
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Danio rerio)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Danio rerio)
NUMB:ITCH [cytosol] (Danio rerio)
Ub-DTX:ITCH [cytosol] (Danio rerio)
DTX:ITCH [cytosol] (Danio rerio)
as an input of
ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)
NUMB binds ITCH (Danio rerio)
ITCH binds DTX (Danio rerio)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
as a member of
RIP2 ubiquitin ligases [cytosol] (Danio rerio)
Inferred From
WWP1/ITCH [cytosol]
(Homo sapiens)
ITCH [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001289155.1
ZFIN
ZDB-GENE-131024-2
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