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traf3 [cytosol]
Stable Identifier
R-DRE-936402
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
K63polyUb-TRAF3, Q6DEG0
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Danio rerio)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Danio rerio)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Danio rerio)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Danio rerio)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
OPTN binds TBK1 within the activated TLR4 complex (Danio rerio)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Danio rerio)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Danio rerio)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
TBK1 is phosphorylated within the activated TLR4 complex (Danio rerio)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Danio rerio)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
traf3 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q6DEG0
Gene Names
traf3
Reference Genes
BioGPS Gene:445119 traf3
ENSEMBL:ENSDARG00000022000
KEGG:dre:445119 traf3
Monarch:445119 traf3
NCBI Gene:445119 traf3
UCSC:Q6DEG0 traf3
Reference Transcript
RefSeq:NM_001003513.1 traf3
Other Identifiers
13052733
445119
A_15_P107142
A_15_P207551
CJ003391
CJ003392
CJ007589
CJ007590
CJ010320
CJ010321
CJ010847
CJ010848
CJ011106
CJ011107
CJ012471
CJ014343
CJ014488
CUST_6792_PI428451958
DRER03941
ENSDART00000031458
ENSDART00000031458_1
ENSDART00000031458_2
GO:0001817
GO:0002376
GO:0005164
GO:0005515
GO:0006355
GO:0007165
GO:0008063
GO:0008270
GO:0032088
GO:0033209
GO:0042981
GO:0045087
GO:0050688
GO:0098542
GT_Spec_NM_001003513.1_335915
JP003790
JP003791
JP007987
JP007988
JP010718
JP010719
JP011245
JP011246
LOL01509
LOL02016
LOL02017
LOL04595
LOL04596
LOL04597
LOL04598
LOL04599
LOL04600
LOL04601
LOL04602
LOL04604
LOL04605
LOL04606
LOL04607
LOL04608
LOL04610
LOL05323
MADDr01009709
NM_001003513
OTTDART00000017143
Participates
as a component of
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
Other forms of this molecule
traf3 [cytosol]
traf3 [cytosol]
Inferred From
K63polyUb-TRAF3 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001003513.1
ENSEMBL
ENSDARP00000038596
,
ENSDART00000031458
,
ENSDARG00000022000
ZFIN
ZDB-GENE-040801-257
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