Reactome | top3a [nucleoplasm]

top3a [nucleoplasm]

Stable Identifier

R-DRE-912452

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

TOP3A, X1WCF3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - G2/M Checkpoints (Danio rerio)
    - G2/M DNA damage checkpoint (Danio rerio)
      - ATR phosphorylates TP53 (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)

DNA Repair (Danio rerio)

- DNA Double-Strand Break Repair (Danio rerio)
  - Homology Directed Repair (Danio rerio)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
      - HDR through Homologous Recombination (HRR) (Danio rerio)
        
        D-loop extension by DNA polymerases (Danio rerio)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Homologous DNA Pairing and Strand Exchange (Danio rerio)
        
        CX3 complex binds D-loop structures (Danio rerio)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Danio rerio)
        
        BCDX2 complex stabilizes RAD51 filament (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Resolution of D-Loop Structures (Danio rerio)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Danio rerio)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Danio rerio)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        FIGNL1 binds RAD51 (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        MUS81:EME1,EME2 cleaves D-loop (Danio rerio)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Danio rerio)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
      - HDR through Single Strand Annealing (SSA) (Danio rerio)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA (Danio rerio)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ERCC1:XPF cleaves flaps generated by SSA (Danio rerio)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        LIG1 binds SSA sites (Danio rerio)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
      - Processing of DNA double-strand break ends (Danio rerio)
        
        ATR activation at DNA DSBs (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ATR phosphorylates RPA2 (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Danio rerio)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - Regulation of TP53 Activity (Danio rerio)
        
        Regulation of TP53 Activity through Phosphorylation (Danio rerio)
        
        ATR phosphorylates TP53 (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Danio rerio)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Danio rerio)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Danio rerio)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)
        
        top3a [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:X1WCF3

Gene Names

top3a

Reference Genes

BioGPS Gene:560212 top3a

ENSEMBL:ENSDARG00000052827

KEGG:dre:560212 top3a

Monarch:560212 top3a

NCBI Gene:560212 top3a

UCSC:X1WCF3 top3a

Reference Transcript

RefSeq:XM_683603.10 top3a

Other Identifiers

13177260

560212

A_15_P187866

A_15_P307426

CUST_25608_PI428451953

CUST_3465_PI423953333

CUST_3466_PI423953333

CUST_3467_PI423953333

CUST_3468_PI423953333

CUST_3469_PI423953333

CUST_3470_PI423953333

CUST_3471_PI423953333

CUST_3472_PI423953333

DRER16077

DRER52497

DRER53601

ENSDART00000074749

ENSDART00000074749_1

ENSDART00000074749_2

ENSDART00000102492

GO:0003677

GO:0003824

GO:0003916

GO:0003917

GO:0005694

GO:0006265

GO:0008270

GO:0016853

GO:0140097

GT_Spec_XM_683603.6_350655

XM_681862

XM_683603

Participates

as a component of

BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Danio rerio)

Inferred From

TOP3A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_688695.4

ENSEMBL

ENSDARG00000052827, ENSDART00000154562, ENSDARP00000127896

ZFIN

ZDB-GENE-071212-2

Cite Us!