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MRN [nucleoplasm]
Stable Identifier
R-DRE-75164
Type
Complex
Species
Danio rerio
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular Senescence (Danio rerio)
DNA Damage/Telomere Stress Induced Senescence (Danio rerio)
KAT5 acetylates ATM at DNA DSBs (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
KAT5 acetylates ATM at shortened telomeres (Danio rerio)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN activates ATM (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN bound to shortened telomeres activates ATM (Danio rerio)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex binds DNA double strand breaks (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex binds shortened telomeres (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex bound to DNA ends recruits ATM (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex bound to shortened telomeres recruits ATM (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA Repair (Danio rerio)
DNA Double-Strand Break Repair (Danio rerio)
DNA Double Strand Break Response (Danio rerio)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Danio rerio)
ATM phosphorylates NBN (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Sensing of DNA Double Strand Breaks (Danio rerio)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
KAT5 acetylates ATM at DNA DSBs (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN activates ATM (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex binds DNA double strand breaks (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex bound to DNA ends recruits ATM (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through MMEJ (alt-NHEJ) (Danio rerio)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
LIG3 ligates remaining SSBs in MMEJ (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN complex binds RBBP8 (Danio rerio)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
mre11a [nucleoplasm]
(Danio rerio)
nbn [nucleoplasm]
(Danio rerio)
RAD50 [nucleoplasm]
(Danio rerio)
Participates
as an output of
LIG3 ligates remaining SSBs in MMEJ (Danio rerio)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)
as a component of
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
as an input of
MRN complex binds shortened telomeres (Danio rerio)
MRN complex binds DNA double strand breaks (Danio rerio)
Inferred From
MRN [nucleoplasm]
(Homo sapiens)
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