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nbn [nucleoplasm]
Stable Identifier
R-DRE-75163
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
nucleoplasm
Synonyms
NBN, Q5I2W8
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular Senescence (Danio rerio)
DNA Damage/Telomere Stress Induced Senescence (Danio rerio)
KAT5 acetylates ATM at DNA DSBs (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
KAT5 acetylates ATM at shortened telomeres (Danio rerio)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN activates ATM (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN bound to shortened telomeres activates ATM (Danio rerio)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex binds DNA double strand breaks (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex binds shortened telomeres (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex bound to DNA ends recruits ATM (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex bound to shortened telomeres recruits ATM (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
Shortened telomere:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA Repair (Danio rerio)
DNA Double-Strand Break Repair (Danio rerio)
DNA Double Strand Break Response (Danio rerio)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Danio rerio)
ATM phosphorylates NBN (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Sensing of DNA Double Strand Breaks (Danio rerio)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
KAT5 acetylates ATM at DNA DSBs (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
KPNA2 translocates NBN to the nucleus (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN activates ATM (Danio rerio)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex binds DNA double strand breaks (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex bound to DNA ends recruits ATM (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through MMEJ (alt-NHEJ) (Danio rerio)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
LIG3 ligates remaining SSBs in MMEJ (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN complex binds RBBP8 (Danio rerio)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
DNA DSBs:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Danio rerio)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Danio rerio)
MRN [nucleoplasm] (Danio rerio)
nbn [nucleoplasm] (Danio rerio)
External Reference Information
External Reference
UniProt:Q5I2W8
Gene Names
nbn
Reference Genes
BioGPS Gene:544655 nbn
ENSEMBL:ENSDARG00000040303
KEGG:dre:544655 nbn
Monarch:544655 nbn
NCBI Gene:544655 nbn
UCSC:Q5I2W8 nbn
Reference Transcript
RefSeq:NM_001014819.1 nbn
Other Identifiers
13031678
544655
A_15_P289686
A_15_P395070
A_15_P631531
CUST_15531_PI428451953
CUST_15532_PI428451953
CUST_15781_PI428451953
CUST_15782_PI428451953
CUST_33_PI424165564
CUST_34_PI424165564
CUST_35_PI424165564
CUST_36_PI424165564
CUST_37_PI424165564
CUST_38_PI424165564
CUST_39_PI424165564
CUST_40_PI424165564
CUST_7201_PI424165604
CUST_7202_PI424165604
CUST_7203_PI424165604
CUST_7204_PI424165604
CUST_7205_PI424165604
CUST_7206_PI424165604
CUST_7207_PI424165604
CUST_7208_PI424165604
DRER07852
DRER21226
DRER30985
DRER42858
DRER47368
Dr.17261.1.A1_at
ENSDART00000058974
ENSDART00000058974_1
ENSDART00000058974_2
ENSDART00000114320
GO:0000723
GO:0005515
GO:0005634
GO:0006281
GO:0006302
GO:0006974
GO:0007093
GO:0007095
GO:0030870
GO:0032200
GT_Spec_XM_005158137.1_408985
GT_Xhyb_NM_001135978.1_375825
LOLS11842
NM_001014819
TC252641
TC261801
XM_693867
XM_694016
ZV700S00002417
Participates
as an input of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)
as a component of
MRN [nucleoplasm] (Danio rerio)
as an output of
KPNA2 translocates NBN to the nucleus (Danio rerio)
Other forms of this molecule
nbn [cytosol]
phospho-nbn [nucleoplasm]
Inferred From
NBN [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001014819.1
ENSEMBL
ENSDART00000058974
,
ENSDARP00000058973
,
ENSDARG00000040303
ZFIN
ZDB-GENE-041008-35
PRO
Q5I2W8
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