Reactome | CDK7 [nucleoplasm]

CDK7 [nucleoplasm]

Stable Identifier

R-DRE-69218

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

Q2V6H0

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- Nucleotide Excision Repair (Danio rerio)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
    - Formation of Incision Complex in GG-NER (Danio rerio)
      - TFIIH binds GG-NER site to form a verification complex (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
    - Dual incision in TC-NER (Danio rerio)
      - 3' incision by ERCC5 (XPG) in TC-NER (Danio rerio)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Danio rerio)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - ERCC5 and RPA bind TC-NER site (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
    - Formation of TC-NER Pre-Incision Complex (Danio rerio)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Danio rerio)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - ERCC8 (CSA) binds stalled RNA Pol II (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - RNA Pol II initiates transcription from damaged DNA template (Danio rerio)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Danio rerio)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Danio rerio)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Danio rerio)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        CAK [nucleoplasm] (Danio rerio)
        
        CDK7 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q2V6H0

Reference Genes

BioGPS Gene:405897

ENSEMBL:ENSDARG00000051916

KEGG:dre:405897

Monarch:405897

NCBI Gene:405897

UCSC:Q2V6H0

Reference Transcript

RefSeq:NM_212961.2

Other Identifiers

13208046

405897

A_15_P116575

BC067643

CJ012594

DRER06219

DRER09893

Dr.3533.1.S1_at

ENSDART00000051003

ENSDART00000051003_1

ENSDART00000051003_2

ENSDART00000073627

GO:0003824

GO:0004672

GO:0005524

GO:0005675

GO:0006468

GO:0008353

GO:0016740

GO:0070985

GO:0140096

GT_Spec_XM_005165671.1_178625

LOLS14516

MADDr01006745

NM_212961

OTTDART00000023097

OTTDART00000023098

Participates

as an input of

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)

as a component of

Inferred From

CDK7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_998126.2

ENSEMBL

ENSDARP00000051002, ENSDARG00000051916, ENSDART00000051003

ZFIN

ZDB-GENE-010320-2

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