Reactome | gnb4b [cytosol]

gnb4b [cytosol]

Stable Identifier

R-DRE-6814417

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

GNB4, A0A2R8RKX9

Locations in the PathwayBrowser

Expand all

Hemostasis (Danio rerio)

- Platelet activation, signaling and aggregation (Danio rerio)
  - Signal amplification (Danio rerio)
    - ADP signalling through P2Y purinoceptor 12 (Danio rerio)
      - Gi activation by P2Y purinoceptor 12 (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
    - Thromboxane signalling through TP receptor (Danio rerio)
      - G13 activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
      - Gq activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
  - Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
    - Thrombin-activated PARs activate Gq (Danio rerio)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
      - Opioid Signalling (Danio rerio)
        
        G-protein activation (Danio rerio)
        
        The receptor:G-protein complex binds GTP (Danio rerio)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        The receptor:G-protein complex releases GDP (Danio rerio)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
      - Opsins act as GEFs for G alpha-t (Danio rerio)
        
        G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
    - G alpha (z) signalling events (Danio rerio)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class B/2 (Secretin family receptors) (Danio rerio)
      - Glucagon-type ligand receptors (Danio rerio)
        
        GLP1R binds GLP1 (Danio rerio)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        gnb4b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A2R8RKX9

Gene Names

gnb4b

Reference Genes

BioGPS Gene:492811 gnb4b

CTD Gene:492811 gnb4b

ENSEMBL:ENSDARG00000115383

Monarch:492811 gnb4b

NCBI Gene:492811 gnb4b

UCSC:A0A2R8RKX9 gnb4b

Reference Transcript

RefSeq:XM_021479603.2 gnb4b

Other Identifiers

12976537

13284788

492811

A_15_P339470

A_15_P397170

A_15_P461630

A_15_P569652

CUST_10161_PI428451958

DRER05453

Dr.3765.1.A1_at

ENSDART00000045015

ENSDART00000045015_1

ENSDART00000045015_2

GO:0005515

GO:0007165

LOLS02434

NM_001007452

TC254779

ZV700S00005137

Participates

as a member of

as a candidate of

Other forms of this molecule

gnb4b [plasma membrane]

Inferred From

Unfolded GNB4 [cytosol] (Homo sapiens)

Partially folded GNB4 [cytosol] (Homo sapiens)

GNB4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_021335278.1

ENSEMBL

ENSDART00000191417, ENSDARP00000147599, ENSDARG00000115383

ZFIN

ZDB-GENE-041114-167

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