Reactome | gnb1b [cytosol]

gnb1b [cytosol]

Stable Identifier

R-DRE-6814412-2

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

GNB1, Q803H5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Danio rerio)

- Cellular responses to mechanical stimuli (Danio rerio)
  - Response of endothelial cells to shear stress (Danio rerio)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Danio rerio)
      - ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Danio rerio)
        
        ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

Hemostasis (Danio rerio)

- Platelet activation, signaling and aggregation (Danio rerio)
  - Signal amplification (Danio rerio)
    - ADP signalling through P2Y purinoceptor 12 (Danio rerio)
      - Gi activation by P2Y purinoceptor 12 (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
    - Thromboxane signalling through TP receptor (Danio rerio)
      - G13 activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - Gq activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
  - Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
    - Thrombin-activated PARs activate Gq (Danio rerio)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

Metabolism (Danio rerio)

- Integration of energy metabolism (Danio rerio)
  - Regulation of insulin secretion (Danio rerio)
    - Adrenaline,noradrenaline inhibits insulin secretion (Danio rerio)
      - Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
        
        G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)
        
        Adenylate cyclase type V or VI: G-protein beta gamma Complex [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Danio rerio)
      - GLP1R binds GLP1 (Danio rerio)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - GLP1R binds GLP1R agonists (Danio rerio)
        
        GLP1R:GLP1R agonists [plasma membrane] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Protein folding (Danio rerio)
  - Chaperonin-mediated protein folding (Danio rerio)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Danio rerio)
      - ATP binds G-protein beta associated TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - PDCL binds G-protein beta and TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - PDCL releases folded G-beta from TRiC/CCT (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - Opioid Signalling (Danio rerio)
        
        G-protein activation (Danio rerio)
        
        The receptor:G-protein complex binds GTP (Danio rerio)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        The receptor:G-protein complex releases GDP (Danio rerio)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - Opsins act as GEFs for G alpha-t (Danio rerio)
        
        G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
    - G alpha (z) signalling events (Danio rerio)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class B/2 (Secretin family receptors) (Danio rerio)
      - Glucagon-type ligand receptors (Danio rerio)
        
        GLP1R binds GLP1 (Danio rerio)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

Transport of small molecules (Danio rerio)

- Aquaporin-mediated transport (Danio rerio)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q803H5

Gene Names

gnb1b

Reference Genes

BioGPS Gene:406796 gnb1b

CTD Gene:406796 gnb1b

ENSEMBL:ENSDARG00000104372

KEGG:dre:406796 gnb1b

Monarch:406796 gnb1b

NCBI Gene:406796 gnb1b

UCSC:Q803H5 gnb1b

Reference Transcript

Other Identifiers

13217053

13217118

406796

A_15_P101091

A_15_P101327

A_15_P107031

A_15_P117452

A_15_P186261

A_15_P257751

A_15_P568562

A_15_P630931

A_15_P703966

A_15_P723026

BC044482.1

DRER01864

DRER12787

DRER35332

Dr.26330.1.S1_at

Dr.6708.1.A1_at

ENSDART00000015309

ENSDART00000015309_y_1

ENSDART00000015309_y_2

ENSDART00000084989

ENSDART00000084989_1

GO:0005515

GO:0007165

GT_Xhyb_XM_005155862.1_149846

GT_Xhyb_XM_005155863.1_303115

GT_Xhyb_XM_005155879.1_302415

GT_Xhyb_XM_005155880.1_72841

GT_Xhyb_XM_005155881.1_302405

GT_Xhyb_XM_005155882.1_72831

LOLS12282

LOLS15370

NM_213481

ZV700S00004748

ZV700S00005935

Participates

as a member of

Homologues of GNB1 [cytosol] (Danio rerio)

Other forms of this molecule

gnb1b [photoreceptor disc membrane]

gnb1b [plasma membrane]

Inferred From

Unfolded GNB1 [cytosol] (Homo sapiens)

Partially folded GNB1 [cytosol] (Homo sapiens)

GNB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998646.1, XP_009300988.1

ENSEMBL

ENSDART00000191740, ENSDART00000172465, ENSDARP00000133655, ENSDARG00000104372, ENSDARP00000140354, ENSDARP00000157643, ENSDART00000163867

ZFIN

ZDB-GENE-040426-2855

PRO

Q803H5

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