Reactome | gnb1 [cytosol]

gnb1 [cytosol]

Stable Identifier

R-DRE-6814412

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

GNB1, Q6PH57

Locations in the PathwayBrowser

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Cellular responses to stimuli (Danio rerio)

- Cellular responses to mechanical stimuli (Danio rerio)
  - Response of endothelial cells to shear stress (Danio rerio)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Danio rerio)
      - ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Danio rerio)
        
        ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

Hemostasis (Danio rerio)

- Platelet activation, signaling and aggregation (Danio rerio)
  - Signal amplification (Danio rerio)
    - ADP signalling through P2Y purinoceptor 12 (Danio rerio)
      - Gi activation by P2Y purinoceptor 12 (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
    - Thromboxane signalling through TP receptor (Danio rerio)
      - G13 activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - Gq activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
  - Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
    - Thrombin-activated PARs activate Gq (Danio rerio)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

Metabolism (Danio rerio)

- Integration of energy metabolism (Danio rerio)
  - Regulation of insulin secretion (Danio rerio)
    - Adrenaline,noradrenaline inhibits insulin secretion (Danio rerio)
      - Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
        
        G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)
        
        Adenylate cyclase type V or VI: G-protein beta gamma Complex [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Danio rerio)
      - GLP1R binds GLP1 (Danio rerio)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - GLP1R binds GLP1R agonists (Danio rerio)
        
        GLP1R:GLP1R agonists [plasma membrane] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Protein folding (Danio rerio)
  - Chaperonin-mediated protein folding (Danio rerio)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Danio rerio)
      - ATP binds G-protein beta associated TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - PDCL binds G-protein beta and TRiC/CCT (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - PDCL releases folded G-beta from TRiC/CCT (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        G-protein beta 1-4 subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Danio rerio)
        
        Unfolded G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - Opioid Signalling (Danio rerio)
        
        G-protein activation (Danio rerio)
        
        The receptor:G-protein complex binds GTP (Danio rerio)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        The receptor:G-protein complex releases GDP (Danio rerio)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G protein-GDP complex [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - Opsins act as GEFs for G alpha-t (Danio rerio)
        
        G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G protein-GTP [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
    - G alpha (z) signalling events (Danio rerio)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class B/2 (Secretin family receptors) (Danio rerio)
      - Glucagon-type ligand receptors (Danio rerio)
        
        GLP1R binds GLP1 (Danio rerio)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

Transport of small molecules (Danio rerio)

- Aquaporin-mediated transport (Danio rerio)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein beta subunit [cytosol] (Danio rerio)
        
        Homologues of GNB1 [cytosol] (Danio rerio)
        
        gnb1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PH57

Gene Names

gnb1

Reference Genes

BioGPS Gene:322104 gnb1

CTD Gene:322104 gnb1

ENSEMBL:ENSDARG00000090454

KEGG:dre:322104 gnb1

Monarch:322104 gnb1

NCBI Gene:322104 gnb1

UCSC:Q6PH57 gnb1

Reference Transcript

RefSeq:NM_212609.1 gnb1

Other Identifiers

13256774

322104

A_15_P112374

A_15_P227176

A_15_P311121

A_15_P434020

A_15_P488000

A_15_P502612

A_15_P673541

A_15_P678836

A_15_P724436

A_15_P747561

A_15_P755393

CJ013200

CUST_3867_PI428451958

DRER30142

Dr.20008.3.A1_at

Dr.26493.1.A1_a_at

GO:0005515

GO:0007165

GT_Spec_NM_212609.1_288215

GT_Xhyb_XM_005167348.1_356905

GT_Xhyb_XM_005167349.1_280845

GT_Xhyb_XM_005167350.1_280855

LOLS05288

LOLS09109

ZV700S00003250

ZV700S00004831

Participates

as a member of

Homologues of GNB1 [cytosol] (Danio rerio)

Other forms of this molecule

gnb1 [photoreceptor disc membrane]

gnb1 [plasma membrane]

Inferred From

Unfolded GNB1 [cytosol] (Homo sapiens)

Partially folded GNB1 [cytosol] (Homo sapiens)

GNB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_997774.1

ENSEMBL

ENSDARP00000150406, ENSDART00000184212, ENSDARP00000111963, ENSDART00000130104, ENSDARG00000090454

ZFIN

ZDB-GENE-030131-823

PRO

Q6PH57

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