Reactome | POLR2I [nucleoplasm]

POLR2I [nucleoplasm]

Stable Identifier

R-DRE-63525

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

Q1LVK2

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- Nucleotide Excision Repair (Danio rerio)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
    - Dual incision in TC-NER (Danio rerio)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Formation of TC-NER Pre-Incision Complex (Danio rerio)
      - UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Transcription of DNA Repair Genes (Danio rerio)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Danio rerio)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Danio rerio)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - RNA Pol II CTD phosphorylation and interaction with CE (Danio rerio)
    - Activation of GT (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - RNA polymerase II transcribes snRNA genes (Danio rerio)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Integrator complex processes the 3' end of snRNA (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)

Metabolism of RNA (Danio rerio)

- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - mRNA Splicing (Danio rerio)
    - mRNA Splicing - Major Pathway (Danio rerio)
      - Formation of the Spliceosomal P complex and exon ligation (Danio rerio)
        
        Spliceosomal C* complex [nucleoplasm] (Danio rerio)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
        
        Spliceosomal P complex [nucleoplasm] (Danio rerio)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
- mRNA Capping (Danio rerio)
  - Activation of GT (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - Capping complex formation (Danio rerio)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Capping complex (initial) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - Dissociation of transcript with 5'-GMP from GT (Danio rerio)
    - Capping complex (GpppN..) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - Formation of the CE:GMP intermediate complex (Danio rerio)
    - Capping complex (intermediate) [nucleoplasm] (Danio rerio)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Danio rerio)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Capping complex (hydrolyzed) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)
    - Capping complex (hydrolyzed) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Capping complex (initial) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)
    - Capping complex (intermediate) [nucleoplasm] (Danio rerio)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Danio rerio)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)
    - Capping complex (GpppN..) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Danio rerio)
        
        POLR2I [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q1LVK2

Reference Genes

BioGPS Gene:449992

ENSEMBL:ENSDARG00000040443

ENSEMBL:ENSDARG00000040443.6

ENSEMBL:ENSDARG00000110652.1

KEGG Gene (Danio rerio):449992

Monarch:449992

NCBI Gene:449992

Reference Transcript

RefSeq:NM_001006013.3

Other Identifiers

13065047

449992

A_15_P117542

A_15_P119697

A_15_P168516

A_15_P470585

A_15_P631161

CJ004990

CUST_2385_PI424165564

CUST_2386_PI424165564

CUST_2387_PI424165564

CUST_2388_PI424165564

CUST_2389_PI424165564

CUST_2390_PI424165564

CUST_2391_PI424165564

CUST_2392_PI424165564

CUST_24_PI428451961

DRER07891

DRER14848

DRER34399

Dr.21233.1.S1_at

ENSDART00000059196

ENSDART00000059196_x_1

ENSDART00000059196_x_2

ENSDART00000064849_x_1

ENSDART00000064849_x_2

GO:0000428

GO:0001193

GO:0003676

GO:0003824

GO:0003899

GO:0005634

GO:0005654

GO:0005665

GO:0005730

GO:0006281

GO:0006283

GO:0006351

GO:0006367

GO:0006379

GO:0008270

GO:0016071

GO:0016740

GO:0043226

GO:0046872

GO:0140098

GT_Spec_NM_001006013.3_241355

JP005389

LOLS03030

MADDr01014668

NM_001006013

OTTDART00000016045

OTTDART00000016178

OTTDART00000016179

XM_679560

Participates

as a component of

Inferred From

POLR2I [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001006013.2

ZFIN

ZDB-GENE-041010-106

Ensembl

ENSDARG00000110652, ENSDARG00000040443, ENSDARP00000059195, ENSDARP00000147976, ENSDART00000059196, ENSDART00000189528

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