Reactome | phospho-hist2h3ca1 [nucleoplasm]

phospho-hist2h3ca1 [nucleoplasm]

Stable Identifier

R-DRE-5625859

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

p-T12,MeK-10-HIST1H3A, A0A140LG23

Locations in the PathwayBrowser

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Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases activate PKNs (Danio rerio)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Danio rerio)
        
        KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        phospho-hist2h3ca1 [nucleoplasm] (Danio rerio)
        
        KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        phospho-hist2h3ca1 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A140LG23

Gene Names

hist2h3ca1

Reference Genes

BioGPS Gene:368227 hist2h3ca1

ENSEMBL:ENSDARG00000105508

KEGG:dre:368227 hist2h3ca1

Monarch:368227 hist2h3ca1

NCBI Gene:368227 hist2h3ca1

UCSC:A0A140LG23 hist2h3ca1

Reference Transcript

Other Identifiers

13285896

368227

A_15_P199611

ENSDART00000097807

ENSDART00000097807_x_1

ENSDART00000097807_x_2

GO:0000786

GO:0003677

GO:0005198

GO:0030527

GO:0046982

XM_677616

Participates

as a component of

Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Danio rerio)

Other forms of this molecule

hist2h3ca1 [nucleoplasm]

hist2h3ca1 [cytosol]

hist2h3ca1 [nucleoplasm]

hist2h3ca1 [extracellular region]

hist2h3ca1 [nucleoplasm]

phospho-hist2h3ca1 [nucleoplasm]

hist2h3ca1 [nucleoplasm]

Inferred From

p-T12,MeK-10-H3 [nucleoplasm] (Homo sapiens)

p-T12,MeK-10-HIST1H3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6-methyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6-methyl-L-lysine [MOD:00085]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine.

Name

O-phospho-L-threonine at 12 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_009301168.1, NP_001353364.1

ENSEMBL

ENSDART00000173105, ENSDARP00000142201, ENSDARG00000105508

ZFIN

ZDB-GENE-030722-8