Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
fadd [cytosol]
Stable Identifier
R-DRE-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
FADD, A0A0R4IXF0
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Danio rerio)
Apoptosis (Danio rerio)
Caspase activation via extrinsic apoptotic signalling pathway (Danio rerio)
Caspase activation via Death Receptors in the presence of ligand (Danio rerio)
Dimerization of procaspase-8 (Danio rerio)
FAS-mediated dimerization of procaspase-8 (Danio rerio)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Danio rerio)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Danio rerio)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNF-mediated dimerization of procaspase-8 (Danio rerio)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAIL-mediated dimerization of procaspase-8 (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
Regulation by c-FLIP (Danio rerio)
Caspase-8 and FLIP(L) processing at DISC (Danio rerio)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Danio rerio)
DISC:procaspase-8 [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Danio rerio)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Danio rerio)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Danio rerio)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
Regulated Necrosis (Danio rerio)
RIPK1-mediated regulated necrosis (Danio rerio)
Regulation of necroptotic cell death (Danio rerio)
CASP8 activity is inhibited (Danio rerio)
FLIP(L) and procaspase-8 form heterodimer (Danio rerio)
DISC:procaspase-8 [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Danio rerio)
DISC:procaspase-8 [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
FLIP(S) and procaspase-8 form heterodimer (Danio rerio)
DISC:procaspase-8 [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Danio rerio)
DISC:procaspase-8 [plasma membrane] (Danio rerio)
DISC [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
RIPK1 is cleaved by CASP8 (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signaling (Danio rerio)
TNF signaling (Danio rerio)
Regulation of TNFR1 signaling (Danio rerio)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Danio rerio)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
RIPK1 is cleaved by CASP8 (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
RIPK1 is cleaved by CASP8:FLIP(L) (Danio rerio)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Danio rerio)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNFR1-induced proapoptotic signaling (Danio rerio)
TRADD:TRAF2:RIP1 binds FADD (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAIL signaling (Danio rerio)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
fadd [cytosol] (Danio rerio)
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP10(1-521) [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
fadd [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A0R4IXF0
Gene Names
fadd
Reference Genes
BioGPS Gene:562317 fadd
ENSEMBL:ENSDARG00000103021
KEGG:dre:562317 fadd
Monarch:562317 fadd
NCBI Gene:562317 fadd
UCSC:A0A0R4IXF0 fadd
Reference Transcript
RefSeq:NM_001386360.1 fadd
Other Identifiers
13231503
562317
A_15_P145096
A_15_P549657
CJ006230
CJ006231
CJ006242
CJ006243
CJ006247
CJ006248
CJ008070
CJ008071
CJ010337
CJ010338
CJ010920
CJ010921
CJ012476
CJ012507
CJ012983
CJ014430
CJ014491
DrAffx.2.52.S1_at
ENSDART00000098288
ENSDART00000098288_1
ENSDART00000098288_2
GO:0005515
GO:0007165
GO:0042981
GT_Spec_XM_001923858.4_9891
JP006628
JP006629
JP006640
JP006641
JP006645
JP006646
JP008468
JP008469
JP010735
JP010736
JP011318
JP011319
TC242683
XM_685706
Participates
as a component of
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Danio rerio)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Danio rerio)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Danio rerio)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Danio rerio)
as an input of
TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)
TRADD:TRAF2:RIP1 binds FADD (Danio rerio)
Inferred From
FADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001373289.1
ENSEMBL
ENSDARG00000103021
,
ENSDART00000172396
,
ENSDARP00000140007
ZFIN
ZDB-GENE-070606-3
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text