Reactome | prkab1a [cytosol]

prkab1a [cytosol]

Stable Identifier

R-DRE-380968

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

PRKAB1, Q6DHM2

Locations in the PathwayBrowser

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Autophagy (Danio rerio)

- Macroautophagy (Danio rerio)
  - AMPK (complex) phosphorylates ULK1 (complex) (Danio rerio)
    - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
      - p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
  - Thr-180 of ULK1 is phosphorylated (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
  - ULK complex translocates to the ER (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
  - p-AMPK:AMP binds the ULK complex (Danio rerio)
    - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
      - p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Danio rerio)
      - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)
    - p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
      - p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Metabolic Genes (Danio rerio)
        
        SESN1,2,3 bind AMPK (Danio rerio)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer:AMP [cytosol] (Danio rerio)
        
        p-AMPK heterotrimer [cytosol] (Danio rerio)
        
        prkab1a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DHM2

Gene Names

prkab1a

Reference Genes

BioGPS Gene:436905 prkab1a

CTD Gene:436905 prkab1a

ENSEMBL:ENSDARG00000044183

KEGG:dre:436905 prkab1a

Monarch:436905 prkab1a

NCBI Gene:436905 prkab1a

UCSC:Q6DHM2 prkab1a

Reference Transcript

Other Identifiers

12962320

436905

A_15_P108117

A_15_P121269

A_15_P529567

CJ002685

CJ002686

CUST_13268_PI428451953

CUST_7748_PI428451958

DRER09135

DRER44790

ENSDART00000064866

ENSDART00000064866_1

ENSDART00000064866_2

GO:0005515

GT_Xhyb_NM_001002632.1_286065

GT_Xhyb_XM_005155628.1_255845

JP002874

JP002875

LOLS05435

MADDr01009495

NM_001002632

OTTDART00000028360

OTTDART00000028361

XM_680690

XM_703009

XM_703010

XM_703011

XM_703012

Participates

as a component of

Other forms of this molecule

prkab1a [nucleoplasm]

Inferred From

AMPK beta [cytosol] (Homo sapiens)

PRKAB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005155685.1, NP_001002632.1

ENSEMBL

ENSDART00000064866, ENSDARP00000064865, ENSDARG00000044183

ZFIN

ZDB-GENE-040718-377

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