Reactome | ADCY4 [plasma membrane]

ADCY4 [plasma membrane]

Stable Identifier

R-DRE-379054

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

F1Q5J6

Locations in the PathwayBrowser

Expand all

Neuronal System (Danio rerio)

- Transmission across Chemical Synapses (Danio rerio)
  - Neurotransmitter receptors and postsynaptic signal transmission (Danio rerio)
    - GABA receptor activation (Danio rerio)
      - GABA B receptor activation (Danio rerio)
        
        Activation of GABAB receptors (Danio rerio)
        
        Adenylate cyclase inhibitory pathway (Danio rerio)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Dissociation of the Gi alpha:G olf complex (Danio rerio)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)

Signal Transduction (Danio rerio)

- Intracellular signaling by second messengers (Danio rerio)
  - DAG and IP3 signaling (Danio rerio)
    - CaM pathway (Danio rerio)
      - Calmodulin induced events (Danio rerio)
        
        PKA-mediated phosphorylation of CREB (Danio rerio)
        
        PKA activation (Danio rerio)
        
        Adenylate cyclase produces cAMP (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Opioid Signalling (Danio rerio)
        
        G-protein mediated events (Danio rerio)
        
        Adenylate cyclase activating pathway (Danio rerio)
        
        Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylate cyclase inhibitory pathway (Danio rerio)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Dissociation of the Gi alpha:G olf complex (Danio rerio)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        PLC beta mediated events (Danio rerio)
        
        Ca-dependent events (Danio rerio)
        
        CaM pathway (Danio rerio)
        
        Calmodulin induced events (Danio rerio)
        
        PKA-mediated phosphorylation of CREB (Danio rerio)
        
        PKA activation (Danio rerio)
        
        Adenylate cyclase produces cAMP (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
    - G alpha (z) signalling events (Danio rerio)
      - G alpha (z) inhibits adenylate cyclase (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Danio rerio)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Danio rerio)
        
        Adenylate cyclase [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)
- Signaling by Hedgehog (Danio rerio)
  - Hedgehog 'off' state (Danio rerio)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)
      - adenylate cyclases:Mg2+ [plasma membrane] (Danio rerio)
        
        adenylate cyclases [plasma membrane] (Danio rerio)
        
        ADCY4 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:F1Q5J6

Reference Genes

BioGPS Gene:557902

CTD Gene:557902

ENSEMBL:ENSDARG00000014588

Monarch:557902

NCBI Gene:557902

UCSC:F1Q5J6

Reference Transcript

RefSeq:XM_005170038.5

Other Identifiers

13075436

557902

A_15_P147881

CJ013160

CUST_20431_PI428451953

CUST_9137_PI428451958

DRER05617

DRER34699

ENSDART00000046166

ENSDART00000046166_1

ENSDART00000046166_2

GO:0003824

GO:0004016

GO:0005886

GO:0006171

GO:0009190

GO:0009975

GO:0016829

GO:0016849

GO:0035556

GO:0055086

GO:1901135

GT_Spec_XM_005170038.1_369925

GT_Xhyb_NM_001099987.1_110912

GT_Xhyb_XM_005170039.1_369935

MADDr01006427

OTTDART00000020608

XM_681057

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Danio rerio)

as a member of

Adenylate cyclase [plasma membrane] (Danio rerio)

Other forms of this molecule

ADCY2 [plasma membrane]

Inferred From

ADCY4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005170095.1

ENSEMBL

ENSDARG00000014588, ENSDART00000046166, ENSDARP00000046165

ZFIN

ZDB-GENE-060503-69

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