Reactome | kdm4ab [nucleoplasm]

kdm4ab [nucleoplasm]

Stable Identifier

R-DRE-351646

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

KDM4A, F1QNG0

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- DNA Double-Strand Break Repair (Danio rerio)
  - DNA Double Strand Break Response (Danio rerio)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Danio rerio)
      - ATM phosphorylates HERC2 (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - KDM4A,B bind H4K20Me2 (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - RNF168 binds DNA DSBs (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Danio rerio)
        
        KDM4A,B [nucleoplasm] (Danio rerio)
        
        kdm4ab [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QNG0

Gene Names

kdm4ab

Reference Genes

BioGPS Gene:334347 kdm4ab

CTD Gene:334347 kdm4ab

ENSEMBL:ENSDARG00000019103

KEGG:dre:334347 kdm4ab

Monarch:334347 kdm4ab

NCBI Gene:334347 kdm4ab

UCSC:F1QNG0 kdm4ab

Reference Transcript

RefSeq:XM_001339628.9 kdm4ab

Other Identifiers

13087754

13087759

334347

A_15_P107615

A_15_P120474

A_15_P494862

BC047193.1

CUST_14684_PI428451953

CUST_14685_PI428451953

CUST_4081_PI423952288

CUST_4082_PI423952288

CUST_4083_PI423952288

CUST_4084_PI423952288

CUST_4085_PI423952288

CUST_4086_PI423952288

CUST_4087_PI423952288

CUST_4088_PI423952288

CUST_577_PI424165973

CUST_578_PI424165973

CUST_579_PI424165973

CUST_580_PI424165973

CUST_581_PI424165973

CUST_582_PI424165973

CUST_583_PI424165973

CUST_584_PI424165973

DRER03131

Dr.24248.1.S1_at

ENSDART00000009989_1

ENSDART00000009989_2

ENSDART00000024302

GT_Spec_XM_001339628.5_191325

MADDr01001245

MADDr01012974

OTTDART00000031727

XM_688139

Participates

as a member of

Other forms of this molecule

kdm4ab [nucleoplasm]

Inferred From

KDM2A, KDM2B, KDM4A [nucleoplasm] (Homo sapiens)

KDM4A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001339664.2

ENSEMBL

ENSDARG00000019103, ENSDARP00000009763, ENSDART00000024302

ZFIN

ZDB-GENE-030131-6279

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