Reactome | col1a1b [extracellular region]

col1a1b [extracellular region]

Stable Identifier

R-DRE-2127355

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

3x4Hyp-COL3A1, Q6PEI9

Locations in the PathwayBrowser

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Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Assembly of collagen fibrils and other multimeric structures (Danio rerio)
    - Formation of collagen fibres (Danio rerio)
      - Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type III fibre [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
    - Formation of collagen fibrils (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Removal of fibrillar collagen C-propeptides (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
- Degradation of the extracellular matrix (Danio rerio)
  - Collagen degradation (Danio rerio)
    - Collagen type III degradation by MMP1,8,9,13 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP14 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP15 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
- ECM proteoglycans (Danio rerio)
  - VTN binds collagens II, III and V (Danio rerio)
    - Collagens [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
    - VTN:Collagen types II,III,V [extracellular region] (Danio rerio)
      - Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
- Non-integrin membrane-ECM interactions (Danio rerio)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
    - Collagens [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Danio rerio)
      - Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - PDGF binds to extracellular matrix proteins (Danio rerio)
      - Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)
      - PDGF A and B chains:ECM complex [extracellular region] (Danio rerio)
        
        Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)
        
        col1a1b [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PEI9

Gene Names

col1a1b

Reference Genes

BioGPS Gene:325675 col1a1b

CTD Gene:325675 col1a1b

ENSEMBL:ENSDARG00000035809

KEGG:dre:325675 col1a1b

Monarch:325675 col1a1b

NCBI Gene:325675 col1a1b

UCSC:Q6PEI9 col1a1b

Reference Transcript

RefSeq:NM_201478.1 col1a1b

Participates

as a member of

Homologues of 3x4Hyp-COL3A1 [extracellular region] (Danio rerio)

Other forms of this molecule

col1a1b [endoplasmic reticulum lumen]

col1a1b [extracellular region]

Inferred From

3x4Hyp-COL3A1 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Cross References

RefSeq

NP_958886.1

ZFIN

ZDB-GENE-030131-4400

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