Reactome | fem1b [cytosol]

fem1b [cytosol]

Stable Identifier

R-DRE-201572

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

FEM1B, E7F7Y4

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Danio rerio)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL2-box protein [cytosol] (Danio rerio)
        
        fem1b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:E7F7Y4

Gene Names

fem1b

Reference Genes

BioGPS Gene:567119 fem1b

ENSEMBL:ENSDARG00000062636

KEGG:dre:567119 fem1b

Monarch:567119 fem1b

NCBI Gene:567119 fem1b

UCSC:E7F7Y4 fem1b

Other Identifiers

13159047

567119

A_15_P136111

DRER13834

Dr.23965.1.A1_at

ENSDART00000090803

ENSDART00000090803_1

ENSDART00000090803_2

GO:0005515

GT_Spec_XM_690410.5_427825

LOLS02244

XM_690410

ZV700S00004066

Participates

as a member of

CUL2-box protein [cytosol] (Danio rerio)

Inferred From

FEM1B [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSDARG00000062636, ENSDARP00000085236, ENSDART00000090803

ZFIN

ZDB-GENE-071009-3