Reactome | SRC-2 [cytosol]

SRC-2 [cytosol]

Stable Identifier

R-DRE-191648

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

Q1JPZ3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Danio rerio)

- Integrin signaling (Danio rerio)
  - Autophosphorylation of SRC (Danio rerio)
    - SRC-2 [cytosol] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by SCF-KIT (Danio rerio)
    - Dimerization of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Disassociation and translocation of STATs to the nucleus (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - JAK2 binds to p-KIT (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Phosphorylation of JAK2 (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Phosphorylation of SHP2 by SFKs (Danio rerio)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Phosphorylation of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Recruitment of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Regulation of KIT signaling (Danio rerio)
      - Phosphorylation of APS (Danio rerio)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - Recruitment of CBL to KIT (Danio rerio)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
    - Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
  - Signaling by VEGF (Danio rerio)
    - VEGFA-VEGFR2 Pathway (Danio rerio)
      - Phosphorylation of SRC-1 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)
      - VEGFR2 mediated cell proliferation (Danio rerio)
        
        SFKs phosphorylate PLCG1 (Danio rerio)
        
        SRC-2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q1JPZ3

Reference Genes

BioGPS Gene:325084

ENSEMBL:ENSDARG00000008107

KEGG Gene (Danio rerio):325084

Monarch:325084

NCBI Gene:325084

Reference Transcript

RefSeq:NM_001003837.2

Other Identifiers

13136073

325084

A_15_P103012

A_15_P134806

A_15_P567222

CJ003296

CJ006319

CJ006321

CUST_285_PI428451958

DRER16208

DRER19535

Dr.2731.1.S1_at

ENSDART00000018738_1

ENSDART00000018738_2

ENSDART00000102843

GT_Xhyb_NM_001003837.2_419555

GT_Xhyb_XM_005174130.1_68011

JP003666

JP006717

JP006719

LOL00231

LOL01231

LOL01767

LOL03349

LOL05075

LOLS06247

MADDr01007228

NM_001003837

OTTDART00000026959

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

SRC [cytosol]

phospho-p-Y419-SRC [cytosol]

MyrG-SRC [plasma membrane]

phospho-p-Y419-SRC [cytosol]

phospho-MyrG,p-Y530-SRC [plasma membrane]

SRC-1 [plasma membrane]

phospho-MyrG-p-Y419-SRC [plasma membrane]

Inferred From

Activated SRC-1 [cytosol] (Homo sapiens)

SRC-2 [cytosol] (Homo sapiens)

SRC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001003837.2

ZFIN

ZDB-GENE-030131-3809

Ensembl

ENSDART00000184254, ENSDARP00000093618, ENSDART00000102843, ENSDARG00000008107, ENSDARP00000151348

PRO

Q1JPZ3

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