Reactome | mature beta-NGF homodimer [extracellular region]

mature beta-NGF homodimer [extracellular region]

Stable Identifier

R-DRE-187031

Type

Complex

Species

Danio rerio

Compartment

extracellular region

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 ngf [extracellular region] (Danio rerio)

Participates

as a component of

RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Danio rerio)
mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
beta-NGF dimer:TrkA receptor [plasma membrane] (Danio rerio)
Activated TrkA receptor complex [plasma membrane] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)

as an input of

NGF binding to p75NTR inactivates RHOA (Danio rerio)
NGF homodimer binds to p75NTR (Danio rerio)
beta-NGF dimer binds to TrkA receptor (Danio rerio)

as an output of

Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)

Inferred From

mature beta-NGF homodimer [extracellular region] (Homo sapiens)

beta-NGF homodimer [extracellular region] (Homo sapiens)